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GlossaryOuter Root Sheath Keratinocytes (ORSCs)

specialized cells in the hair follicle's outer layer

Outer Root Sheath Keratinocytes are specialized cells found in the outer layer of the hair follicle. These cells play a crucial role in the growth and regeneration of hair, as they provide structural support and contribute to the formation of the hair shaft. For professionals, it's important to note that these keratinocytes are involved in the hair cycle's anagen (growth) phase and can be a focus in studies related to hair loss and treatments for conditions like alopecia.

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research Restructuring Skin Equivalents With Human Hair Follicle ORSCs and Fibroblasts

March 2007 in “Journal of Plastic Reconstructive & Aesthetic Surgery”

A new method was developed to create better skin models for healing and reconstruction.

research The Effect of Topical Hair Growth Promoters on Internal Calcium of Human Outer Root Sheath Cells (ORSCs)

June 1996 in “Journal of Dermatological Science”

research The Chemotactic Effect of a Dermal Papilla Cell-Derived Factor on Outer Root Sheath Cells

47 citations , April 2001 in “Journal of Dermatological Science”

IGF-I and HGF attract and stimulate hair follicle cells to move.

research Hair Follicle Stem Cell Replication Stress Drives IFI16/STING-Dependent Inflammation in Hidradenitis Suppurativa

33 citations , April 2020 in “Journal of Clinical Investigation”

Stress in hair follicle stem cells causes inflammation in a chronic skin condition through a specific immune response pathway.

research The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms

21 citations , April 2018 in “Journal of Dermatological Science”

Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.

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community If PP405 works it will be fkn impossible to buy it.

in Technology 91 upvotes 2 months ago

PP405 is a potential hair loss treatment that may activate dormant hair follicles, but there are concerns about its effectiveness, cost, and side effects. Users discuss treatments like minoxidil, finasteride, and RU58841, expressing skepticism about PP405's long-term success and accessibility.