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GlossaryPolycomb Repressive Complex 2 (PRC2)

regulates gene expression by modifying chromatin structure

Polycomb Repressive Complex 2 (PRC2) is a group of proteins that play a crucial role in regulating gene expression by modifying chromatin, the material that makes up chromosomes. PRC2 adds a specific chemical mark to histones (proteins around which DNA is wrapped), leading to the repression of genes that are not needed at certain times or in certain cell types. This process is essential for proper development and cellular differentiation.

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research Dermal EZH2 Orchestrates Dermal Differentiation and Epidermal Proliferation During Murine Skin Development

6 citations, June 2021 in “Developmental biology”

Dermal EZH2 controls skin cell development and hair growth in mice.

research Polycomb Repressive Complex 2 in Adult Hair Follicle Stem Cells Is Dispensable for Hair Regeneration

6 citations, December 2021 in “PLoS Genetics”

Polycomb Repressive Complex 2 is not needed for hair regeneration.

research Polycomb-Mediated Repression and Sonic Hedgehog Signaling Regulate Merkel Cell Specification

April 2016 in “Journal of Investigative Dermatology”

Sonic hedgehog signaling is needed for the development of touch-receptor cells in the skin, and the loss of Polycomb repressive complex 2 can lead to more of these cells.

Dermal EZH2 Simultaneously Orchestrates Wnt/β-Catenin Signaling Dependent Dermal Differentiation and Retinoic Acid Signaling Dependent Epidermal Proliferation During Murine Skin Development

research Dermal EZH2 Simultaneously Orchestrates Wnt/β-Catenin Signaling Dependent Dermal Differentiation and Retinoic Acid Signaling Dependent Epidermal Proliferation During Murine Skin Development

November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Ezh2 controls skin development by balancing signals for dermal and epidermal growth.

Catalytic-Dependent and -Independent Activities of Polycomb Repressive Complex 1 Differentially Regulate Skin Stem Cell Specification

research Catalytic-Dependent and -Independent Activities of Polycomb Repressive Complex 1 Differentially Regulate Skin Stem Cell Specification

April 2017 in “Journal of Investigative Dermatology”

PRC1 influences skin stem cell development by both turning genes on and off, affecting hair growth and skin cell types.

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