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    Glossary Polycomb Repressive Complex 2

    regulates gene expression by modifying chromatin structure

    Polycomb Repressive Complex 2 (PRC2) is a group of proteins that play a crucial role in regulating gene expression by modifying chromatin, the material that makes up chromosomes. PRC2 adds a specific chemical mark to histones (proteins around which DNA is wrapped), leading to the repression of genes that are not needed at certain times or in certain cell types. This process is essential for proper development and cellular differentiation.

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    Research 10 of 188

    1. Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration PLoS Genetics · 2021 · 6 citations
    2. 708 Polycomb-mediated repression and Sonic hedgehog signaling regulate Merkel cell specification Journal of Investigative Dermatology · 2016
    3. Aguas residuales urbanas Horticultura: Revista de industria, distribución y socioeconomía hortícola: frutas, hortalizas, flores, plantas, árboles ornamentales y viveros · 1997 · 9 citations
    4. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    5. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    6. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    7. POLYCOMB REPRESSIVE COMPLEX 1 IS REQUIRED TO MAINTAIN STEM CELL IDENTITY AND TO PRESERVE ADULT TISSUE HOMEOSTASIS. Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · 2020
    8. 864 Catalytic-dependent and -independent activities of Polycomb repressive complex 1 differentially regulate skin stem cell specification Journal of Investigative Dermatology · 2017
    9. 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification Journal of Investigative Dermatology · 2018 · 1 citations
    10. PRC 2 preserves intestinal progenitors and restricts secretory lineage commitment EMBO journal · 2016 · 75 citations
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