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    Glossary Polycomb Repressive Complex 2

    regulates gene expression by modifying chromatin structure

    Polycomb Repressive Complex 2 (PRC2) is a group of proteins that play a crucial role in regulating gene expression by modifying chromatin, the material that makes up chromosomes. PRC2 adds a specific chemical mark to histones (proteins around which DNA is wrapped), leading to the repression of genes that are not needed at certain times or in certain cell types. This process is essential for proper development and cellular differentiation.

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    Research 30 of 189

    1. Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration PLoS Genetics · 2021 · 6 citations
    2. 708 Polycomb-mediated repression and Sonic hedgehog signaling regulate Merkel cell specification Journal of Investigative Dermatology · 2016
    3. Aguas residuales urbanas Horticultura: Revista de industria, distribución y socioeconomía hortícola: frutas, hortalizas, flores, plantas, árboles ornamentales y viveros · 1997 · 9 citations
    4. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    5. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    6. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    7. POLYCOMB REPRESSIVE COMPLEX 1 IS REQUIRED TO MAINTAIN STEM CELL IDENTITY AND TO PRESERVE ADULT TISSUE HOMEOSTASIS. Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · 2020
    8. 864 Catalytic-dependent and -independent activities of Polycomb repressive complex 1 differentially regulate skin stem cell specification Journal of Investigative Dermatology · 2017
    9. 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification Journal of Investigative Dermatology · 2018 · 1 citations
    10. PRC 2 preserves intestinal progenitors and restricts secretory lineage commitment EMBO journal · 2016 · 75 citations
    11. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    12. Tailored chromatin modulation to promote tissue regeneration Seminars in Cell & Developmental Biology · 2019 · 10 citations
    13. Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation Frontiers in Cell and Developmental Biology · 2026
    14. DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells Else Kröner-Fresenius Symposia · 2012
    15. Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011 · 191 citations
    16. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    17. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair Genes & Development · 2011 · 354 citations
    18. Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease Stem cell biology and regenerative medicine · 2018
    19. Epigenetic regulation in adult stem cells and cancers Cell & Bioscience · 2013 · 20 citations
    20. ATP-dependent chromatin remodeling during mammalian development Development · 2016 · 182 citations
    21. The Epithelial Stem Cell Niche in Skin Elsevier eBooks · 2017 · 9 citations
    22. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    23. Second International Symposium—Epigenetic Regulation of Skin Regeneration and Aging: From Chromatin Biology towards the Understanding of Epigenetic Basis of Skin Diseases 2017 · 2 citations
    24. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    25. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    26. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    27. A matter of life and death: self‐renewal in stem cells EMBO Reports · 2012 · 150 citations
    28. The Pharmacology of Regenerative Medicine Pharmacological Reviews · 2013 · 47 citations
    29. Androgen receptor: A promising therapeutic target in breast cancer Critical Reviews in Clinical Laboratory Sciences · 2019 · 21 citations
    30. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations