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    Glossary Polycomb Repressive Complex 2

    regulates gene expression by modifying chromatin structure

    Polycomb Repressive Complex 2 (PRC2) is a group of proteins that play a crucial role in regulating gene expression by modifying chromatin, the material that makes up chromosomes. PRC2 adds a specific chemical mark to histones (proteins around which DNA is wrapped), leading to the repression of genes that are not needed at certain times or in certain cell types. This process is essential for proper development and cellular differentiation.

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    Research 30 of 168

    1. Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration PLoS Genetics · 2021 · 6 citations
    2. 708 Polycomb-mediated repression and Sonic hedgehog signaling regulate Merkel cell specification Journal of Investigative Dermatology · 2016
    3. Aguas residuales urbanas Horticultura: Revista de industria, distribución y socioeconomía hortícola: frutas, hortalizas, flores, plantas, árboles ornamentales y viveros · 1997 · 9 citations
    4. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    5. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    6. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    7. POLYCOMB REPRESSIVE COMPLEX 1 IS REQUIRED TO MAINTAIN STEM CELL IDENTITY AND TO PRESERVE ADULT TISSUE HOMEOSTASIS. Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · 2020
    8. 864 Catalytic-dependent and -independent activities of Polycomb repressive complex 1 differentially regulate skin stem cell specification Journal of Investigative Dermatology · 2017
    9. 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification Journal of Investigative Dermatology · 2018 · 1 citations
    10. PRC 2 preserves intestinal progenitors and restricts secretory lineage commitment EMBO journal · 2016 · 75 citations
    11. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    12. Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation Frontiers in Cell and Developmental Biology · 2026
    13. Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011 · 191 citations
    14. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    15. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair Genes & Development · 2011 · 354 citations
    16. Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease Stem cell biology and regenerative medicine · 2018
    17. Epigenetic regulation in adult stem cells and cancers Cell & Bioscience · 2013 · 20 citations
    18. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    19. Second International Symposium—Epigenetic Regulation of Skin Regeneration and Aging: From Chromatin Biology towards the Understanding of Epigenetic Basis of Skin Diseases 2017 · 2 citations
    20. ATP-dependent chromatin remodeling during mammalian development Development · 2016 · 182 citations
    21. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    22. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    23. A matter of life and death: self‐renewal in stem cells EMBO Reports · 2012 · 150 citations
    24. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    25. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    26. Emerging roles of transit‐amplifying cells in tissue regeneration and cancer Wiley Interdisciplinary Reviews-Developmental Biology · 2017 · 32 citations
    27. Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche Nature Reviews Molecular Cell Biology · 2013 · 133 citations
    28. GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states PLOS Genetics · 2017 · 38 citations
    29. The Pharmacology of Regenerative Medicine Pharmacological Reviews · 2013 · 47 citations
    30. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations