Polycomb Repressive Complex 2 in Adult Hair Follicle Stem Cells Is Dispensable for Hair Regeneration

    December 2021 in “ PLoS Genetics
    Pooja Flora, Meng-Yen Li, Phillip M. Galbo, Maider Astorkia, Deyou Zheng, Elena Ezhkova
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    TLDR Polycomb Repressive Complex 2 is not needed for hair regeneration.
    This study investigates the role of Polycomb Repressive Complex 2 (PRC2) in adult hair follicle stem cells (HFSCs) and its necessity for hair regeneration. Despite previous suggestions that PRC2-mediated tri-methylation of histone H3 at lysine 27 (H3K27me3) might be crucial for HFSC function, in vivo loss-of-function studies reveal that PRC2 is non-essential for maintaining HFSC quiescence or cell identity. The absence of PRC2 does not disrupt HFSC quiescence, although it leads to the upregulation of genes associated with the activated state of HFSCs. These findings indicate that the transcriptional program regulated by PRC2 is not required for hair regeneration.
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