A Hairy Situation: PADIs in Regeneration and Alopecia

    December 2021 in “ Frontiers in Cell and Developmental Biology ”
    Kim Vikhe Patil, Kylie Hin-Man Mak, Maria Genander
    Studysummary This review outlines how peptidyl arginine deiminases (PADIs) and protein citrullination are involved in hair follicle regeneration and inflammatory alopecia, but presents no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 29

    1. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    2. Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases International Journal of Molecular Sciences · 2020
    3. Pathomechanisms of Immune-Mediated Alopecia International Immunology · 2019
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    6. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
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    8. Primary Cicatricial Alopecia: Treatment Approaches and Classification Journal of The American Academy of Dermatology · 2016
    9. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    10. Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata The Journal of Dermatology · 2015
    11. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    12. Divergent Roles of HDAC1 and HDAC2 in the Regulation of Epidermal Development and Tumorigenesis The EMBO Journal · 2013
    13. Reciprocal Role of Vitamin D Receptor on β-Catenin Regulated Keratinocyte Proliferation and Differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013
    14. Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis Journal of Investigative Dermatology · 2013
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    18. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    19. Does Collapse of Immune Privilege in the Hair-Follicle Bulge Play a Role in the Pathogenesis of Primary Cicatricial Alopecia? Clinical and Experimental Dermatology · 2009
    20. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008
    21. Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer Journal of biological chemistry/˜The œJournal of biological chemistry · 2007
    22. Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata Journal of Clinical Investigation · 2007
    23. Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata The American Journal of Human Genetics · 2007
    24. Peptidylarginine Deiminase Isoforms Are Differentially Expressed in Anagen Hair Follicles and Other Human Skin Appendages Journal of Investigative Dermatology · 2005
    25. Trichohyalin Mechanically Strengthens the Hair Follicle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    26. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
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    28. The Fate of Trichohyalin Journal of biological chemistry/˜The œJournal of biological chemistry · 1997
    29. The Origin of Citrulline-Containing Proteins in the Hair Follicle and the Chemical Nature of Trichohyalin, an Intracellular Precursor Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 1977

    Related research 2

    1. A Hairy Situation: PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021
    2. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015