The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

    January 2008 in “ PloS one ”
    Héctor G. Pálmer, Fernando Anjos‐Afonso, Geert Carmeliet … Fiona M. Watt
    Studysummary This study observed that the vitamin D receptor is crucial for hair follicle formation and altering tumor development in the Wnt signaling pathway, suggesting therapeutic potential for vitamin D analogues in related tumors.
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    Research cited in this study 10

    1. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    2. Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells Genes & development · 2005
    3. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004
    4. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    5. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    6. Vitamin D3 Analogs Stimulate Hair Growth in Nude Mice Endocrinology · 2002
    7. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    8. Metabolic And Cellular Analysis Of Alopecia In Vitamin D Receptor Knockout Mice Journal of Clinical Investigation · 2001
    9. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    10. Cytokeratin 15 Expression in Trichoepitheliomas and a Subset of Basal Cell Carcinomas Suggests They Originate from Hair Follicle Stem Cells Journal of Cutaneous Pathology · 1999

    Related research 5

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    2. The Wave Complex Controls Epidermal Morphogenesis and Proliferation by Suppressing Wnt-Sox9 Signaling The Journal of Cell Biology · 2019
    3. MicroRNA-214 Controls Skin and Hair Follicle Development by Modulating the Activity of the Wnt Pathway Journal of Cell Biology · 2014
    4. The Hair Cycle and Vitamin D Receptor Archives of Biochemistry and Biophysics · 2011
    5. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008