Primary Cicatricial Alopecia

November 2016 in “ Journal of The American Academy of Dermatology ”

Chantal Bolduc, Leonard C. Sperling, Jerry Shapiro

Studysummary This article reviews various types of primary cicatricial alopecias and emphasizes the importance of accurate diagnosis to improve management strategies, particularly detailing remaining lymphocytic forms and expanding on neutrophilic and mixed types.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Erosive Pustular Dermatosis of the Scalp Successfully Treated with Oral Prednisone and Topical Tacrolimus

16 citations , October 2013 in “Anais Brasileiros de Dermatologia”

In this case report, an elderly woman with erosive pustular dermatosis of the scalp showed complete closure of eroded areas after treatment with prednisone and topical tacrolimus, resulting in stable scarring alopecia.

research Long-Term Remission of Folliculitis Decalvans After Treatment with the Long-Pulsed Nd:YAG Laser

27 citations , July 2013 in “Journal of dermatological treatment”

This report describes a case where a recalcitrant folliculitis decalvans was successfully treated with a long-pulsed Nd:YAG laser.

research Clinical Effects of Non-Ablative and Ablative Fractional Lasers on Various Hair Disorders: A Case Series of 17 Patients

46 citations , March 2013 in “Journal of Cosmetic and Laser Therapy”

This study found that non-ablative and/or ablative fractional lasers promoted hair growth in patients with certain uncommon hair disorders, though effectiveness varied among different conditions.

research Central Centrifugal Cicatricial Alopecia: Possible Familial Aetiology in Two African Families from South Africa

15 citations , November 2012 in “International Journal of Dermatology”

This case series observed a potential familial link in central centrifugal cicatricial alopecia (CCCA), suggesting a genetic predisposition that may be worsened by hair grooming practices.

research Histopathology of Scarring and Nonscarring Hair Loss

17 citations , September 2012 in “Dermatologic Clinics”

This review discusses histologic findings in alopecia and emphasizes the importance of understanding normal follicular anatomy and cycles in transverse sections, without reporting new results.

research The Efficacy of Laser-Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae: A Pilot Study

40 citations , September 2012 in “European Journal of Dermatology”

This study found that long pulsed Nd-YAG laser treatment significantly improved acne keloidalis nuchae by reducing inflammation and hair follicles, with early intervention yielding the best results.

research Hair Breakage as a Presenting Sign of Early or Occult Central Centrifugal Cicatricial Alopecia

44 citations , September 2012 in “Archives of Dermatology”

This study observed that hair breakage may indicate early central centrifugal cicatricial alopecia in African American women, suggesting that it should be considered in their differential diagnosis.

research Photodynamic Therapy for the Treatment of Folliculitis Decalvans

25 citations , March 2012 in “Photodermatology Photoimmunology & Photomedicine”

This case report describes a patient with folliculitis decalvans who successfully responded to photodynamic therapy.

research Central Centrifugal Cicatricial Alopecia: An Approach to Diagnosis and Management

32 citations , November 2011 in “International Journal of Dermatology”

This article reviews central centrifugal cicatricial alopecia, focusing on its multifactorial etiology and challenges in clinical diagnosis, and calls for more research and better treatment options.

research Erosive Pustular Dermatosis And Associated Alopecia Successfully Treated With Topical Tacrolimus

22 citations , August 2011 in “Journal of the American Academy of Dermatology”

This article highlights that erosive pustular dermatosis of the scalp is often under-diagnosed in the United States, potentially leading to unnecessary surgery.

research Prevalence and Etiology of Central Centrifugal Cicatricial Alopecia

19 citations , August 2011 in “Archives of Dermatology”

This abstract contains no research findings but is a snippet of a website interface for JAMA Dermatology.

research Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia

88 citations , April 2011 in “Archives of Dermatology”

This study found a high prevalence of central hair loss among African American women and associated it with diabetes mellitus type 2, bacterial scalp infections, and hairstyles causing traction.

research Central Hair Loss in African American Women: Incidence and Potential Risk Factors

76 citations , November 2010 in “Journal of The American Academy of Dermatology”

In this study, a photographic scale and questionnaire revealed that extensive central scalp hair loss was observed in 5.6% of African American women, with an association to a history of tinea capitis.

research Acne Keloidalis Nuchae: A Case Series of Four Indian Patients

40 citations , May 2010 in “American Journal of Clinical Dermatology”

This study reports that four Indian patients with acne keloidalis nuchae also exhibited acanthosis nigricans, suggesting a potential link to metabolic syndrome, though further research is needed to confirm this association.

research Effective Treatment of Folliculitis Decalvans Using Selected Antimicrobial Agents

33 citations , January 2010 in “International journal of trichology”

This case series reports 13 patients with folliculitis decalvans treated with antimicrobial therapy, highlighting the variability in response outcomes for this challenging condition.

research Histopathology of Alopecia: A Clinicopathological Approach to Diagnosis

170 citations , December 2009 in “Histopathology”

This review discusses the histopathological diagnosis of scarring and non-scarring alopecias, emphasizing the importance of adequate tissue sampling and clinical information; it reports no new empirical results.

research Central Centrifugal Cicatricial Alopecia: Past, Present, and Future

75 citations , March 2009 in “Journal of The American Academy of Dermatology”

This review discusses the evolution and ongoing debate about the causes of central centrifugal cicatricial alopecia in African American women, without presenting new clinical findings.

research Erosive Pustular Dermatosis of the Scalp Following Topical Methylaminolaevulinate Photodynamic Therapy

52 citations , February 2009 in “Journal of the American Academy of Dermatology”

This case study identified erosive pustular dermatosis of the scalp following methylaminolaevulinate photodynamic therapy, noting improvement with steroid treatment and partial resolution of atrophy after three months.

research Pseudopelade of Brocq: A Review of a Rare Hair Disorder Leading to Cicatricial Alopecia

39 citations , July 2008 in “Dermatologic Therapy”

This review provides a practical approach to diagnosing pseudopelade of Brocq and updates on treatment options but reports no new clinical results.

research Central Centrifugal Cicatricial Alopecia

72 citations , July 2008 in “Dermatologic Therapy”

This article reviews central centrifugal cicatricial alopecia in African-descent females, discussing possible causes, associated styling habits, and potential treatments, but reports no new clinical findings; the authors call for further research.

research Central Scalp Alopecia Photographic Scale in African American Women

46 citations , July 2008 in “Dermatologic Therapy”

This study developed and evaluated a photographic scale to assess CCCA pattern and severity in African American women, finding it reproducible when used by investigators and participants.

research Keratosis Follicularis Spinulosa Decalvans in a Family

32 citations , February 2008 in “Journal of the American Academy of Dermatology”

This case report describes a family with autosomal dominant transmission of keratosis follicularis spinulosa decalvans, with observed treatment refractoriness in multiple topical and systemic therapies.

research Topical Tacrolimus in the Treatment of Erosive Pustular Dermatosis of the Scalp

23 citations , November 2007 in “Journal of cutaneous medicine and surgery”

This case report suggests that topical tacrolimus may effectively manage erosive pustular dermatosis of the scalp and reverse skin atrophy, although long-term use requires monitoring for side effects.

research Erosive Pustular Dermatosis of the Scalp After Perinatal Scalp Injury

38 citations , November 2006 in “Pediatric dermatology”

This study reports four infants with necrotic caput succedaneum leading to alopecia and persistent scalp lesions, which partially improved with topical corticosteroids, indicating erosive pustular dermatosis of the scalp.

research Madarosis

33 citations , November 2006 in “Survey of Ophthalmology”

This report discusses the various causes and clinical assessment of madarosis, emphasizing the importance of recognizing and diagnosing associated vision or life-threatening conditions, without presenting new findings.

research Histopathologic Evaluation of Alopecias

90 citations , June 2006 in “The American Journal of Dermatopathology”

This review outlines the classification, histopathologic presentation, and pathogenetic concepts of scarring and nonscarring alopecias, reporting no new clinical results and emphasizing the need for clinicopathologic correlation.

research The Medical Treatment of Cicatricial Alopecia

46 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

This review discusses treatment strategies for cicatricial alopecia based on histopathologic findings, emphasizing the challenges due to overlapping and evolving histopathologic features, but reports no new clinical results.

research Keratosis Follicularis Spinulosa Decalvans And Acne Keloidalis Nuchae

37 citations , September 2005 in “Australasian Journal of Dermatology”

This case report describes a 27-year-old man with a unique association of keratosis follicularis spinulosa decalvans and acne keloidalis nuchae, successfully treated with oral isotretinoin.

research Hair Loss: Is There a Relationship with Hair Care Practices in Nigeria?

57 citations , September 2005 in “International Journal of Dermatology”

This study reported that chemical relaxants and hair styling practices were associated with scarring hair loss, particularly among women with central centrifugal cicatricial alopecias.

research Modern External Beam Radiation Therapy for Refractory Dissecting Cellulitis of the Scalp

36 citations , April 2005 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, modern radiation therapy techniques rapidly alleviated pain and improved symptoms in patients with severe dissecting cellulitis of the scalp, with no long-term toxicity observed.

research Erosive Pustular Dermatosis of the Scalp: A Case Report and Review of the Literature

49 citations , January 2005 in “Dermatology”

This case study found that isotretinoin treatment achieved complete resolution of erosive pustular dermatosis of the scalp in a patient, suggesting systemic retinoids as a potential treatment option.

research Medical and Surgical Therapies for Alopecias in Black Women

105 citations , April 2004 in “Dermatologic Therapy”

This review discusses medical and surgical therapies for alopecias in Black women, focusing on the impact of hair-care practices and the importance of patient education, but reports no new clinical results.

research Primary Cicatricial Alopecias: Clinicopathology of 112 Cases

254 citations , December 2003 in “Journal of the American Academy of Dermatology”

This study reviewed the epidemiology and treatment of inflammatory cicatricial alopecias and highlighted the importance of scalp biopsies for accurate diagnosis in a mixed ethnic population at a university hair clinic.

research Pseudofolliculitis Barbae and Acne Keloidalis Nuchae

66 citations , October 2003 in “Dermatologic clinics”

Excision and laser techniques can effectively treat acne keloidalis nuchae.

research Ethnic Hair Update: Past and Present

73 citations , June 2003 in “Journal of the American Academy of Dermatology”

This article reviews common hair-care practices among African American patients and discusses how these practices relate to hair and scalp disorders, without presenting new clinical research.

research Alopecia Mucinosa: Report of a Case and Review

21 citations , April 2003 in “Journal of cutaneous medicine and surgery”

This case report describes an instance of idiopathic alopecia mucinosa that achieved complete remission with minocycline and reviews related literature.

research Use of an 800-nm Pulsed-Diode Laser in the Treatment of Recalcitrant Dissecting Cellulitis of the Scalp

51 citations , October 2002 in “Archives of dermatology”

This case study of a patient with dissecting cellulitis of the scalp found that multiple medications, including isotretinoin, achieved only modest improvement, and symptoms returned after treatments were stopped.

research Lymphocytic Mediated Alopecia: Histological Classification by Pattern Analysis

29 citations , March 2001 in “Clinics in Dermatology”

This article discusses various types of primary cicatricial alopecias and reports no new clinical results; it emphasizes the importance of accurate diagnosis for effective management.

research The Surgical Management of Extensive Cases of Acne Keloidalis Nuchae

72 citations , November 2000 in “Archives of Dermatology”

This study found that excision with primary closure is an effective surgical treatment for extensive acne keloidalis nuchae, with good cosmetic results and minimal recurrence observed among patients.

research Simultaneous Occurrence of Folliculitis Decalvans Capillitii in Identical Twins

39 citations , July 2000 in “British Journal of Dermatology”

This report on identical female twins with folliculitis decalvans suggests a possible genetic component to the disease, marking the first such case in twins.

research Pseudopelade of Brocq in Beard Area

24 citations , May 2000 in “Journal of the American Academy of Dermatology”

This case report describes a patient with pseudopelade affecting both the scalp and beard area, highlighting the unusual presentation of a rare hair disorder.

research Folliculitis Decalvans Including Tufted Folliculitis: Clinical, Histological, and Therapeutic Findings

226 citations , February 1999 in “British Journal of Dermatology”

This study reported that a treatment regimen of oral rifampicin and clindamycin for 10 weeks effectively managed folliculitis decalvans, with most patients experiencing no recurrence after one or multiple courses.

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44 citations , November 1998 in “Australasian Journal of Dermatology”

This review provides a framework for diagnosing acquired scalp alopecias and discusses both non-scarring and scarring types, but reports no new clinical results.

research Tufted Hair Folliculitis Developing in a Recalcitrant Lesion of Pemphigus Vulgaris

28 citations , May 1998 in “Journal of the American Academy of Dermatology”

This case report suggests that tufted hair formation can occur in localized exudative inflammatory scalp lesions, as observed in a Japanese man with pemphigus vulgaris.

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19 citations , October 1996 in “International Journal of Dermatology”

This study concluded that pseudopelade is an autosomal dominant condition, distinct from other forms of alopecia, characterized by atrophic hair follicle loss and notable familial association.

research Clinical Findings, Cutaneous Pathology, and Response to Therapy in 21 Patients With Keratosis Pilaris Atrophicans

78 citations , April 1994 in “Archives of dermatology”

This study suggests genetic and clinical heterogeneity in keratosis pilaris atrophicans, with variations in inheritance patterns, severity, and response to treatment among 21 individuals observed.

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18 citations , March 1992 in “Archives of Dermatology”

This case report presents a 28-year-old man with scarring alopecia unresponsive to topical treatments, alongside a family history of keratosis pilaris and unique curly scalp hair.

research Keratosis Follicularis Spinulosa Decalvans: A Family Study of Seven Male Cases and Six Female Carriers

41 citations , January 1992 in “Journal of medical genetics”

This study described seven male patients and six female carriers of keratosis follicularis spinulosa decalvans, highlighting distinct dermatological and ophthalmic markers including follicular hyperkeratosis and corneal dystrophy.

research Inflammatory Tinea Capitis (Kerion) Mimicking Dissecting Cellulitis

44 citations , March 1991 in “International Journal of Dermatology”

This article presents two cases of tinea capitis in postpubertal individuals highlighting the importance of early treatment to prevent scarring and permanent hair loss; it reports no new clinical results.

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78 citations , June 1989 in “The Journal of dermatologic surgery and oncology”

This article reviews acne keloidalis in young black men, describes its clinical and histopathological characteristics, and highlights surgical therapy approaches despite the uncertain etiology of the condition.

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54 citations , January 1983 in “Archives of Dermatology”

This article presents two cases of keratosis follicularis spinulosa decalvans and reviews its features, highlighting characteristic progression from keratosis pilaris in infancy to cicatricial alopecia in childhood.

research Erosive Pustular Dermatosis of the Scalp

187 citations , May 1979 in “British Journal of Dermatology”

In this report, six elderly women with a novel pustular dermatosis of the scalp experienced chronic lesions unresponsive to antibiotics but were effectively managed with potent topical steroids.

research Hot Comb Alopecia

107 citations , September 1968 in “Archives of Dermatology”

In this study, researchers identified a form of irreversible scalp alopecia in Black women using hot combs, characterized by incomplete hair loss primarily on the crown and follicular scarring.

research Follicular Mucinosis (Alopecia Mucinosa)

20 citations , June 1964 in “Archives of Dermatology”

This study described three cases of follicular mucinosis and observed that one case responded rapidly to systemic corticosteroids, suggesting a potential therapeutic effect.