Prevalence and Etiology of Central Centrifugal Cicatricial Alopecia

August 2011 in “ Archives of Dermatology ”

Valerie D. Callender, Oge Onwudiwe

Central Centrifugal Cicatricial Alopecia CCCA scarring hair loss genetics hair grooming habits African hair structure type 2 diabetes bacterial infections fertility issues vitamin D deficiency

TLDR CCCA is a common scarring hair loss in African descent women, possibly linked to genetics, hair care practices, and health issues like diabetes.

The document reviewed Central Centrifugal Cicatricial Alopecia (CCCA), a scarring hair loss condition predominantly affecting African descent women, with unclear etiology but suspected multifactorial causes including genetics, hair grooming habits, and African hair structure. It referenced a study by Kyei et al. with 310 African American women, revealing 28% had central hair loss and 59% of those had severe hair loss, noting a significant link between type 2 diabetes and severe hair loss, as well as higher rates of bacterial infections and fertility issues in CCCA patients. Another study by Olsen et al. with 529 African American women showed a 5.6% prevalence of extensive central alopecia, with a positive correlation between patient age and hair loss severity. The document highlighted the necessity for more research on CCCA, including its possible systemic connections, like diabetes and vitamin D deficiency.

View this study on jamanetwork.com →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia

88 citations, April 2011 in “Archives of Dermatology”

Type 2 diabetes, bacterial scalp infections, and tight hairstyles like braids and weaves are linked to a higher risk of a scarring hair loss condition in African American women.

research Central Hair Loss in African American Women: Incidence and Potential Risk Factors

76 citations, November 2010 in “Journal of The American Academy of Dermatology”

Some African American women's central scalp hair loss is linked to genetics and past fungal scalp infections, with more research needed on other causes.

research Central Scalp Alopecia Photographic Scale in African American Women

46 citations, July 2008 in “Dermatologic Therapy”

A scale was made to measure hair loss severity in African American women.

research Hair Loss: Is There a Relationship with Hair Care Practices in Nigeria?

57 citations, September 2005 in “International Journal of Dermatology”

Frequent use of chemical hair relaxants is linked to increased scarring hair loss in Nigerian women.

research Medical and Surgical Therapies for Alopecias in Black Women

105 citations, April 2004 in “Dermatologic Therapy”

The document concludes that proper diagnosis and a combination of medical, hair-care, and surgical treatments are important for managing alopecia in black women.

research The Ziering Whorl Classification of Scalp Hair

18 citations, July 2003 in “Dermatologic Surgery”

The conclusion is that creating natural-looking hair restoration requires replicating natural scalp whorl patterns and inserting grafts at specific angles.

research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

180 citations, January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is crucial for normal skin and hair growth.

Related Community Posts Join

6 / 59 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 89 upvotes 4 months ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

in Treatment 4 upvotes 5 years ago

Derma rolling, pumpkin seed oil, and daily massages helped regrow weak hairs on the crown. Nizoral shampoo and yoga also contributed to reducing scalp pain and stress.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Exploring Bryan Johnson's Hair Routine In Detail

in Research/Science 64 upvotes 11 months ago

Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

Similar Research

6 / 1000+ results

research Female Adolescent Hair Disorders

20 citations, July 2009 in “Journal of Pediatric and Adolescent Gynecology”

Quick treatment of hair disorders in teenage girls is important because of the emotional effects.

research Current and Emerging Treatment Strategies for Hair Loss in Women of Color

15 citations, January 2019 in “International Journal of Women's Dermatology”

Early treatment helps stop hair loss in women of color.

research A Practical Approach to the Diagnosis and Management of Hair Loss in Children and Adolescents

40 citations, July 2017 in “Frontiers in Medicine”

Early and personalized treatment for hair loss in young people is crucial to prevent permanent damage and should include psychological support.

research Proceedings of the 7th World Congress of Hair Research

1 citations, January 2013 in “International Journal of Trichology”

The conference discussed various hair disorders and treatments, including the use of topical steroids, high doses of cetrizine, and hair grafting, as well as the psychological impact of hair loss.

research Central Centrifugal Cicatricial Alopecia

July 2018

Hair loss in African American women, caused by hair care, genetics, and environment, needs more research for better treatment.

research Central Centrifugal Cicatricial Alopecia: An Approach to Diagnosis and Management

32 citations, November 2011 in “International Journal of Dermatology”

Diagnose and manage CCCA with thorough history, exams, and labs; treat with anti-inflammatory agents, stress reduction, and stopping harmful hair practices.