Prevalence and Etiology of Central Centrifugal Cicatricial Alopecia

    August 2011 in “ Archives of Dermatology ”
    Valerie D. Callender, Oge Onwudiwe
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    TLDR CCCA is a common scarring hair loss in African descent women, possibly linked to genetics, hair care practices, and health issues like diabetes.
    The document reviewed Central Centrifugal Cicatricial Alopecia (CCCA), a scarring hair loss condition predominantly affecting African descent women, with unclear etiology but suspected multifactorial causes including genetics, hair grooming habits, and African hair structure. It referenced a study by Kyei et al. with 310 African American women, revealing 28% had central hair loss and 59% of those had severe hair loss, noting a significant link between type 2 diabetes and severe hair loss, as well as higher rates of bacterial infections and fertility issues in CCCA patients. Another study by Olsen et al. with 529 African American women showed a 5.6% prevalence of extensive central alopecia, with a positive correlation between patient age and hair loss severity. The document highlighted the necessity for more research on CCCA, including its possible systemic connections, like diabetes and vitamin D deficiency.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

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      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 3 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

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      Central Centrifugal Cicatricial Alopecia: A Subtype of Lichen Planopilaris in African Descent?

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      September 2024 in “Portuguese Journal of Dermatology and Venereology”
      Central centrifugal cicatricial alopecia (CCCA) is a scarring hair loss condition primarily affecting middle-aged women of African descent, potentially linked to lichen planopilaris (LPP) due to shared clinical and histological features. Genetic mutations, particularly in the PADI3 gene, and possibly hair grooming practices contribute to its pathogenesis. Despite similarities, CCCA exhibits unique trichoscopic findings and less inflammation compared to LPP. The study suggests that CCCA and LPP may exist on a phenotypic spectrum influenced by genetic and environmental factors. Effective management requires early intervention with behavioral changes and anti-inflammatory treatments, though further research is necessary to enhance understanding and therapy.