Risk Factors and Comorbidities Associated With Central Centrifugal Cicatricial Alopecia

September 2023 in “ International journal of women’s dermatology ”

Maxwell Green, Aileen Feschuk, Manuel Valdebran

Studysummary This study found mixed evidence linking traction hairstyles, previous pregnancies, chemical hair relaxers, and several comorbidities to an increased risk of central centrifugal cicatricial alopecia in Black women.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document reviews 15 studies on Central Centrifugal Cicatricial Alopecia (CCCA), a common form of hair loss primarily affecting Black women aged 30-55. Risk factors for CCCA include type 2 diabetes mellitus, bacterial scalp infection, traction hairstyles, previous pregnancies, use of chemical hair relaxers, and certain hair grooming practices. Comorbidities associated with CCCA include type 2 diabetes mellitus, uterine fibroids, hyperlipidemia, and vitamin D insufficiency/deficiency. However, the results are mixed, with some studies finding no increased risk of comorbidities or no significant difference in rates of depression or anxiety in women with CCCA compared to controls. The document concludes that more research is needed, and that current treatment focuses on anti-inflammatory medications, with potential future use of antifibrotic agents.

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research Central Centrifugal Cicatricial Alopecia in Adolescents: Overview of Literature

5 citations , April 2023 in “Life”

This review discusses central centrifugal cicatricial alopecia in adolescents, noting varied presentation and highlighting genetic and environmental factors, but reports no new clinical findings.

research Increased Risk of Vitamin D Deficiency and Insufficiency in Black Patients With Central Centrifugal Cicatricial Alopecia

3 citations , February 2022 in “Journal of the American Academy of Dermatology”

This article highlights a lack of published data on vitamin D deficiency prevalence among individuals with central centrifugal cicatricial alopecia, despite its known link to other forms of hair loss.

research Association of Breast and Colorectal Cancer in Patients With Central Centrifugal Cicatricial Alopecia: A Retrospective, Cross-Sectional Pilot Study

9 citations , October 2020 in “Journal of the American Academy of Dermatology”

Patients with central centrifugal cicatricial alopecia may have a higher risk of breast and colorectal cancer.

research Association of Type 2 Diabetes With Central-Scalp Hair Loss in a Large Cohort Study of African American Women

16 citations , June 2019 in “International Journal of Women's Dermatology”

This study found that type 2 diabetes was associated with a higher risk of severe central scalp hair loss in African American women.

research Variant PADI3 in Central Centrifugal Cicatricial Alopecia

95 citations , February 2019 in “The New England Journal of Medicine”

This article discusses the potential genetic basis of central centrifugal cicatricial alopecia in women of African ancestry but does not provide new research results.

research Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia

25 citations , June 2018 in “Journal of The American Academy of Dermatology”

This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.

research Vitamin D Status in Scarring and Nonscarring Alopecia

13 citations , April 2018 in “Journal of The American Academy of Dermatology”

This study found that 64.8% of patients with different types of alopecia had vitamin D deficiency, and those with lichen planopilaris and telogen effluvium had higher odds of severe deficiency compared to patients with alopecia areata.

research PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

38 citations , January 2017 in “PPAR Research”

This review discusses the role of PPAR-γ in the pathogenesis of primary cicatricial alopecia, including its involvement in lichen planopilaris and treatment trials using PPAR-agonists, and reports no new clinical results.

research Factors Affecting the Severity of Central Centrifugal Cicatricial Alopecia

29 citations , January 2016 in “International Journal of Dermatology”

This study reports that the duration of hair loss is positively associated with the severity of central centrifugal cicatricial alopecia in African-American women.

research Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia

88 citations , April 2011 in “Archives of Dermatology”

This study found a high prevalence of central hair loss among African American women and associated it with diabetes mellitus type 2, bacterial scalp infections, and hairstyles causing traction.

research Central Centrifugal Cicatricial Alopecia

72 citations , July 2008 in “Dermatologic Therapy”

This article reviews central centrifugal cicatricial alopecia in African-descent females, discussing possible causes, associated styling habits, and potential treatments, but reports no new clinical findings; the authors call for further research.