Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

January 2002 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Zhongjion Xie, László G. Kömüves, Qian–Chun Yu, Hashem Elalieh, Dean Ng, Colin Leary, Sam K. C. Chang, Debra Crumrine, Daniel D. Bikle, Tatsuya Yoshizawa, Shigeaki Kato

Vitamin D Receptor VDR epidermal differentiation hair follicle growth involucrin profilaggrin loricrin alopecia hair follicles dermal cysts Vitamin D Receptor VDR skin differentiation hair growth hair loss skin cysts

TLDR Vitamin D Receptor is crucial for normal skin and hair growth.

The study demonstrated that the absence of the Vitamin D Receptor (VDR) in knockout mice led to significant disruptions in epidermal differentiation and hair follicle growth, resulting in progressive alopecia and nearly total hair loss by 8 months. Histological analysis revealed dilated hair follicles, dermal cysts, and decreased expression of differentiation markers like involucrin, profilaggrin, and loricrin. Despite normal keratin 10 levels, there was a loss of keratohyalin granules in the granular layer. These findings indicated that VDR is crucial for normal epidermal and hair follicle differentiation.

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