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Glossary Skin Cysts

non-cancerous, fluid-filled sacs forming under the skin

Skin cysts, also known as cutaneous cysts or dermal cysts, are non-cancerous, closed pockets of tissue that can be filled with fluid, pus, or other material. They often form as a result of infection, clogged sebaceous glands, or around foreign bodies, and can appear anywhere on the skin. While generally harmless, they can sometimes become painful or infected, necessitating medical evaluation and potential removal.

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Research

5 / 1000+ results

research Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

297 citations , January 2002 in “Development”

In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.

research Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures

5 citations , January 2021 in “Frontiers in cell and developmental biology”

This paper discusses the multipotency of cyst cells and proposes that understanding molecular circuits in cyst formation could enable engineering of desired stem cell culture phenotypes, but reports no new experimental outcomes.

research 190 Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified a mutation in the CST6 gene linked to a rare syndrome with symptoms affecting hair and skin, revealing cystatin M/E's role in maintaining epidermal homeostasis and hair follicle development.

research Convergent Evolution of Cysteine-Rich Keratins in Hard Skin Appendages of Terrestrial Vertebrates

36 citations , November 2019 in “Molecular biology and evolution”

This study suggests that the keratins found in reptile and bird skin appendages evolved independently from mammalian hair keratins, highlighting convergent evolution in these species.

research Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin

10 citations , November 2018 in “Genetics in medicine”

This study identified a genetic variant in the CTS6 gene associated with a hypotrichosis syndrome, emphasizing the significant role of cystatin M/E in hair and skin health.

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Community Join

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community Finasteride/ Dutasteride Cured my Acne.. Anyone else?

9 upvotes 2 weeks ago

Finasteride and dutasteride helped users reduce or eliminate cystic acne and improve skin oiliness. Users reported no negative side effects and unexpected benefits from blocking DHT.

community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

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Learn

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learn Hair Transplant

What are the complications after a hair transplant? Pain and swelling are common. Infection (about 1-2% in the few studies that reported a rate), folliculitis, shock loss, cysts, scarring, poor growth and, rarely, skin necrosis can occur.

learn Melatonin

Can melatonin cause side effects on the skin or hair? No study links melatonin to hair loss; reports are anecdotal. Some users report scalp dryness or irritation from topical products, and a safety review lists mainly mild side effects such as sleepiness and headache.

learn Follistatin

Can follistatin be applied to the skin, and does any form of it treat hair loss? No study shows that follistatin applied to the skin works, and no form of follistatin is an approved or proven hair-loss treatment. Follistatin injections, "research peptides" and gene therapies sold outside regulated trials are unapproved and of unknown safety.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Providers say SMP pigment can be matched to many skin tones and hair colors; claims that it works on all of them are marketing.
Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

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Clinics

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Experts

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SMP Specialist
Noelle Skin
Nice, France