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GlossaryCitrullination

conversion of arginine to citrulline in proteins

Citrullination, also known as deimination, is a post-translational modification where the amino acid arginine in a protein is converted into citrulline. This process is catalyzed by enzymes called peptidylarginine deiminases (PADs) and can affect protein function and structure. Citrullination is involved in various physiological processes and has been linked to autoimmune diseases like rheumatoid arthritis.

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research Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer

62 citations, December 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

A specific chemical change in the S100A3 protein leads to the formation of a four-part structure important for hair formation.

research Citrullination at the Inflammatory Skin Barrier

May 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

A potential treatment for atopic dermatitis could be to increase PADI1 expression to improve skin barrier function.

research Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles

4 citations, January 2017 in “Biological & pharmaceutical bulletin”

Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.

research Citrullinome of Porphyromonas Gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides

21 citations, November 2019 in “Molecular & Cellular Proteomics”

Citrullinated proteins from Porphyromonas gingivalis may contribute to rheumatoid arthritis.

research A Hairy Situation: PADIs in Regeneration and Alopecia

5 citations, December 2021 in “Frontiers in Cell and Developmental Biology”

Enzymes called PADIs play a key role in hair growth and loss.

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