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    Glossary PADI6

    enzyme involved in protein modification and hair follicle formation

    PADI6 stands for Peptidyl Arginine Deiminase, Type VI, an enzyme that plays a role in the post-translational modification of proteins by converting arginine residues into citrulline. This process, known as citrullination, can affect protein function and is involved in various cellular processes, including the regulation of gene expression and the formation of hair follicles. Mutations in the PADI6 gene have been linked to certain types of alopecia and fertility issues.

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    Research 10 of 537

    1. A Hairy Cituation – PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    2. Co-expression of PADI isoforms during progenitor differentiation enables functional diversity Philosophical Transactions of the Royal Society B Biological Sciences · 2023 · 2 citations
    3. The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles Science Advances · 2025
    4. Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles BMC Dermatology · 2020 · 4 citations
    5. Citrullination at the Inflammatory Skin Barrier 2023
    6. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016 · 119 citations
    7. Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019 · 95 citations
    8. Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 49 citations
    9. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    10. Genetic Susceptibility to Alopecia The New England Journal of Medicine · 2019 · 5 citations
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