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GlossaryPeptidyl Arginine Deiminase Type 2

enzyme that converts arginine in proteins to citrulline

Peptidyl Arginine Deiminase Type 2 (PADI2) is an enzyme that converts arginine residues in proteins into citrulline, a process known as citrullination. This modification can affect protein function and is involved in various physiological processes, including the regulation of gene expression and the immune response. PADI2 has been implicated in conditions such as rheumatoid arthritis and certain types of alopecia, where abnormal citrullination may play a role in disease pathology.

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research Citrullinome of Porphyromonas Gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides

21 citations, November 2019 in “Molecular & Cellular Proteomics”

Citrullinated proteins from Porphyromonas gingivalis may contribute to rheumatoid arthritis.

research The Genomic Variation in Textured Hair: Implications in Developing a Holistic Hair Care Routine

October 2024 in “Cosmetics”

Afro-textured hair needs personalized care due to its unique genetic traits.

research A Hairy Situation: PADIs in Regeneration and Alopecia

5 citations, December 2021 in “Frontiers in Cell and Developmental Biology”

Enzymes called PADIs play a key role in hair growth and loss.

research Central Centrifugal Cicatricial Alopecia in Black Men: A Case Series Highlighting Key Clinical Features

2 citations, May 2023 in “JAAD Case Reports”

The document concludes that early and accurate diagnosis of hair loss on the top of the scalp in Black men is important to distinguish CCCA from other types of hair loss.

research The Fate of Trichohyalin

135 citations, October 1997 in “Journal of biological chemistry/The Journal of biological chemistry”

Trichohyalin is modified by enzymes to form strong structures in hair cells.

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