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    Glossary Peptidyl Arginine Deiminase Type 2

    enzyme that converts arginine in proteins to citrulline

    Peptidyl Arginine Deiminase Type 2 (PADI2) is an enzyme that converts arginine residues in proteins into citrulline, a process known as citrullination. This modification can affect protein function and is involved in various physiological processes, including the regulation of gene expression and the immune response. PADI2 has been implicated in conditions such as rheumatoid arthritis and certain types of alopecia, where abnormal citrullination may play a role in disease pathology.

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    1. Isolation and Molecular Cloning of Epidermal- and Hair Follicle-Specific Peptidylarginine Deiminase (Type III) from Rat The Journal of Biochemistry · 1997 · 42 citations
    2. Morphogenesis- and Hair Cycle-dependent Expression of Trichohyalin, Peptidylarginine Deiminase Type III and Deiminated Trichohyalin in Rat Dorsal Skin Hair Follicles Biomedical Research · 2001
    3. Immunocytochemical Localization of Peptidylarginine Deiminase Type III, Trichohyalin and Deiminated Trichohyalin in Infant Rat Dorsal Skin Hair Follicle Biomedical Research · 2001 · 2 citations
    4. Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin 2000 · 124 citations
    5. Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid‐treated culture of a newborn rat keratinocyte cell line FEBS Letters · 1998 · 39 citations
    6. 481 Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2024
    7. Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases International Journal of Molecular Sciences · 2020 · 57 citations
    8. Ca <sup>2+</sup> -mediated protein citrullination regulates proliferation in the regenerating and malignant CNS 2026
    9. Citrullinome of Porphyromonas gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides Molecular & Cellular Proteomics · 2019 · 21 citations
    10. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2025
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