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GlossaryPeptidyl Arginine Deiminase Type 2

enzyme that converts arginine in proteins to citrulline

Peptidyl Arginine Deiminase Type 2 (PADI2) is an enzyme that converts arginine residues in proteins into citrulline, a process known as citrullination. This modification can affect protein function and is involved in various physiological processes, including the regulation of gene expression and the immune response. PADI2 has been implicated in conditions such as rheumatoid arthritis and certain types of alopecia, where abnormal citrullination may play a role in disease pathology.

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research A Hairy Situation: PADIs in Regeneration and Alopecia

5 citations, December 2021 in “Frontiers in Cell and Developmental Biology”

Enzymes called PADIs play a key role in hair growth and loss.

research Central Centrifugal Cicatricial Alopecia in Black Men: A Case Series Highlighting Key Clinical Features

2 citations, August 2023 in “JAAD Case Reports”

The document concludes that early and accurate diagnosis of hair loss on the top of the scalp in Black men is important to distinguish CCCA from other types of hair loss.

research The Fate of Trichohyalin

135 citations, October 1997 in “Journal of biological chemistry/The Journal of biological chemistry”

Trichohyalin is modified by enzymes to form strong structures in hair cells.

research Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin

124 citations, November 2000 in “The journal of investigative dermatology/Journal of investigative dermatology”

PAD3 plays a key role in hair and skin protein structure and may be linked to skin diseases.

research Cardiovascular Risk in Patients With Scarring and Nonscarring Alopecias: Assessing the Current State of Evidence

September 2023 in “JEADV Clinical Practice”

People with common hair loss conditions may have a higher risk of heart disease and related health issues.

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