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GlossaryPeptidyl Arginine Deiminase Type 2

enzyme that converts arginine in proteins to citrulline

Peptidyl Arginine Deiminase Type 2 (PADI2) is an enzyme that converts arginine residues in proteins into citrulline, a process known as citrullination. This modification can affect protein function and is involved in various physiological processes, including the regulation of gene expression and the immune response. PADI2 has been implicated in conditions such as rheumatoid arthritis and certain types of alopecia, where abnormal citrullination may play a role in disease pathology.

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research Peptidylarginine Deiminase Isoforms Are Differentially Expressed in Anagen Hair Follicles and Other Human Skin Appendages

71 citations , June 2005 in “Journal of Investigative Dermatology”

PAD enzymes play a key role in hair growth and structure.

research The Genomic Variation in Textured Hair: Implications in Developing a Holistic Hair Care Routine

October 2024 in “Cosmetics”

Afro-textured hair needs personalized care due to its unique genetic traits.

research Central Centrifugal Cicatricial Alopecia: A Subtype of Lichen Planopilaris in African Descent?

September 2024 in “Portuguese Journal of Dermatology and Venereology”

CCCA and LPP may be related hair loss conditions influenced by genetics and environment, needing early treatment.

research Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases

57 citations , January 2020 in “International Journal of Molecular Sciences”

PADs are crucial for healthy skin and hair, and their imbalance can cause skin and hair disorders.

research Central Centrifugal Cicatricial Alopecia in Black Men: A Case Series Highlighting Key Clinical Features

2 citations , May 2023 in “JAAD Case Reports”

The document concludes that early and accurate diagnosis of hair loss on the top of the scalp in Black men is important to distinguish CCCA from other types of hair loss.

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