Search
for

    Glossary Peptidylarginine Deiminase

    enzyme converting arginine in proteins to citrulline

    Peptidylarginine Deiminase (PAD) is an enzyme that converts arginine residues in proteins into citrulline through a process called deimination or citrullination. This modification can affect protein function and is involved in various physiological processes, including the regulation of gene expression and the formation of hair. Dysregulation of PAD activity has been linked to autoimmune diseases and conditions like alopecia.

    Related Terms

    Research 10 of 111

    1. Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin 2000 · 124 citations
    2. Peptidylarginine Deiminase Isoforms Are Differentially Expressed in the Anagen Hair Follicles and Other Human Skin Appendages Journal of Investigative Dermatology · 2005 · 71 citations
    3. Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases International Journal of Molecular Sciences · 2020 · 57 citations
    4. Isolation and Molecular Cloning of Epidermal- and Hair Follicle-Specific Peptidylarginine Deiminase (Type III) from Rat The Journal of Biochemistry · 1997 · 42 citations
    5. Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid‐treated culture of a newborn rat keratinocyte cell line FEBS Letters · 1998 · 39 citations
    6. Immunocytochemical Localization of Peptidylarginine Deiminase Type III, Trichohyalin and Deiminated Trichohyalin in Infant Rat Dorsal Skin Hair Follicle Biomedical Research · 2001 · 2 citations
    7. Morphogenesis- and Hair Cycle-dependent Expression of Trichohyalin, Peptidylarginine Deiminase Type III and Deiminated Trichohyalin in Rat Dorsal Skin Hair Follicles Biomedical Research · 2001
    8. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2025
    9. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia. PubMed · 2025
    10. 481 Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2024
    All research results →

    Learn

    — no results

    Try a deeper search in learn →

    Community

    — no results

    Try a deeper search in community →