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    Glossary Peptidyl Arginine Deiminase Type 2

    enzyme that converts arginine in proteins to citrulline

    Peptidyl Arginine Deiminase Type 2 (PADI2) is an enzyme that converts arginine residues in proteins into citrulline, a process known as citrullination. This modification can affect protein function and is involved in various physiological processes, including the regulation of gene expression and the immune response. PADI2 has been implicated in conditions such as rheumatoid arthritis and certain types of alopecia, where abnormal citrullination may play a role in disease pathology.

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    Research 30 of 171

    1. Isolation and Molecular Cloning of Epidermal- and Hair Follicle-Specific Peptidylarginine Deiminase (Type III) from Rat The Journal of Biochemistry · 1997 · 42 citations
    2. Morphogenesis- and Hair Cycle-dependent Expression of Trichohyalin, Peptidylarginine Deiminase Type III and Deiminated Trichohyalin in Rat Dorsal Skin Hair Follicles Biomedical Research · 2001
    3. Immunocytochemical Localization of Peptidylarginine Deiminase Type III, Trichohyalin and Deiminated Trichohyalin in Infant Rat Dorsal Skin Hair Follicle Biomedical Research · 2001 · 2 citations
    4. Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin 2000 · 124 citations
    5. Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid‐treated culture of a newborn rat keratinocyte cell line FEBS Letters · 1998 · 39 citations
    6. 481 Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2024
    7. Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases International Journal of Molecular Sciences · 2020 · 57 citations
    8. Ca <sup>2+</sup> -mediated protein citrullination regulates proliferation in the regenerating and malignant CNS 2026
    9. Citrullinome of Porphyromonas gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides Molecular & Cellular Proteomics · 2019 · 21 citations
    10. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2025
    11. Peptidylarginine Deiminase Isoforms Are Differentially Expressed in the Anagen Hair Follicles and Other Human Skin Appendages Journal of Investigative Dermatology · 2005 · 71 citations
    12. A Hairy Cituation – PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    13. The Fate of Trichohyalin 1997 · 135 citations
    14. Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer 2007 · 62 citations
    15. The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles Science Advances · 2025
    16. Editorial: Inflammation, stem cells and wound healing in skin aging Frontiers in Cell and Developmental Biology · 2022
    17. The alopecia areata phenotype is induced by the water avoidance stress test in <i>cchcr1</i>-deficient mice bioRxiv (Cold Spring Harbor Laboratory) · 2020
    18. Genetic Susceptibility to Alopecia The New England Journal of Medicine · 2019 · 5 citations
    19. Integrated Meta-Analysis of Scalp Transcriptomics and Serum Proteomics Defines Alopecia Areata Subtypes and Core Disease Pathways International Journal of Molecular Sciences · 2025
    20. Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence JEADV Clinical Practice · 2023
    21. Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes Journal of Investigative Dermatology · 2004 · 49 citations
    22. Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages Journal of Investigative Dermatology · 2014 · 68 citations
    23. Ottawa, Ontario, Canada, February 13–16, 2013 The Journal of Rheumatology · 2013 · 4 citations
    24. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes 2021 · 11 citations
    25. Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019 · 95 citations
    26. Characteristic Localization of Neuronatin in Rat Testis, Hair Follicle, Tongue, and Pancreas Journal of Histochemistry and Cytochemistry · 2019 · 2 citations
    27. Biology of the wool follicle: an excursion into a unique tissue interaction system waiting to be re‐discovered Experimental Dermatology · 2006 · 117 citations
    28. Computational derivation of a molecular framework for hair follicle biology from disease genes Scientific Reports · 2017 · 4 citations
    29. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    30. Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis 1991 · 48 citations