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    Glossary PADI6

    enzyme involved in protein modification and hair follicle formation

    PADI6 stands for Peptidyl Arginine Deiminase, Type VI, an enzyme that plays a role in the post-translational modification of proteins by converting arginine residues into citrulline. This process, known as citrullination, can affect protein function and is involved in various cellular processes, including the regulation of gene expression and the formation of hair follicles. Mutations in the PADI6 gene have been linked to certain types of alopecia and fertility issues.

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    Research 30 of 537

    1. A Hairy Cituation – PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    2. Co-expression of PADI isoforms during progenitor differentiation enables functional diversity Philosophical Transactions of the Royal Society B Biological Sciences · 2023 · 2 citations
    3. The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles Science Advances · 2025
    4. Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles BMC Dermatology · 2020 · 4 citations
    5. Citrullination at the Inflammatory Skin Barrier 2023
    6. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016 · 119 citations
    7. Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019 · 95 citations
    8. Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 49 citations
    9. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    10. Genetic Susceptibility to Alopecia The New England Journal of Medicine · 2019 · 5 citations
    11. Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles Biological & pharmaceutical bulletin · 2017 · 4 citations
    12. Two siblings with uncombable hair syndrome: A new pathogenic variant Pediatric Dermatology · 2024 · 2 citations
    13. Deimination in epidermal barrier and hair formation Philosophical transactions - Royal Society. Biological sciences · 2023 · 2 citations
    14. Pili trianguli et canaliculi as a phenotypic subtype in patients with central centrifugal cicatricial alopecia: A scanning electron microscopy study Journal of the American Academy of Dermatology · 2020 · 2 citations
    15. Ugreelig hår Tidsskrift for Den norske legeforening · 2022 · 1 citations
    16. Unravelling the threads of central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2026
    17. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2025
    18. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia. PubMed · 2025
    19. 481 Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2024
    20. Central centrifugal cicatricial alopecia: a subtype of lichen planopilaris in African descent? Portuguese Journal of Dermatology and Venereology · 2024
    21. Support for dermatological research in Sub‐Saharan Africa: insights from African hair and skin research programs International Journal of Dermatology · 2024
    22. This month in JAAD Case Reports: October 2023—Central centrifugal cicatricial alopecia in Black men Journal of the American Academy of Dermatology · 2023
    23. Uncombable hair syndrome due to maternal uniparental disomy of chromosome 1 American journal of medical genetics. Part A · 2022
    24. Uncombable hair syndrome and beyond Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.) · 2022
    25. Central Centrifugal Cicatricial Alopecia (CCCA) CRC Press eBooks · 2021
    26. 부챗말 Glucopyranosyldiacylglycerol의 탈모방지 효능 생약학회지 · 2020
    27. Deciphering the pathogenesis of central centrifugal cicatricial alopecia 2019
    28. 284 Deciphering the pathogenesis of central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2019
    29. Hair regrowth in a patient with central centrifugal cicatricial alopecia after a 2-month trial of baricitinib JAAD Case Reports · 2023 · 2 citations
    30. Revisión de compositos de biocerámicas y biopolímeros mediante electrohilado para su uso potencial como andamios para la sustitución de piel PÄDI Boletín Científico de Ciencias Básicas e Ingenierías del ICBI · 2022 · 2 citations