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Glossary Quiescence

state of cellular dormancy without active division

Quiescence refers to a state of inactivity or dormancy in cells, where they are not actively dividing but are still metabolically active. In the context of hair biology, hair follicle stem cells can enter a quiescent state, pausing their growth and division until they receive signals to re-enter the active phase of the hair growth cycle. This process is crucial for maintaining the long-term health and regenerative capacity of hair follicles.

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research Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

200 citations , March 2023 in “Nature Reviews Molecular Cell Biology”

This review discusses the role and regulation of quiescent adult stem cells in tissue maintenance and repair, focusing on molecular mechanisms and their implications for regenerative medicine, but reports no new clinical results.

research Quiescent Tissue Stem Cells Evade Immune Surveillance

169 citations , February 2018 in “Immunity”

In this study, researchers found that quiescent stem cells resist immune attack due to downregulated antigen presentation, which may help explain the immune evasion of early cancer-initiating cells.

research Foxc1 reinforces quiescence in self-renewing hair follicle stem cells

142 citations , February 2016 in “Science”

This review discusses the role of Foxc1 and type XVII collagen in hair follicle stem cell quiescence and aging, identifying mechanisms that relate to hair thinning and hair loss, and reports no new results.

research Stem cell quiescence acts as a tumour suppressor in squamous tumours

66 citations , December 2013 in “Nature Cell Biology”

This study found that quiescence in hair follicle stem cells acts as a tumor suppression mechanism for cutaneous squamous cell carcinoma, with Pten activity necessary to maintain this state.

research The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

35 citations , July 2018 in “Cell Reports”

This study found that the dermal papilla of the hair follicle regulates stem cell quiescence and regeneration by modulating Shh and Wnt signaling pathways, highlighting the importance of signaling cross talk in regeneration.

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community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 1 year ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

community Relax to grow more hair. Study title: Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

6 upvotes 5 years ago

Relaxation may promote hair growth by reducing corticosterone, which affects hair follicle stem cells. Corticosteroids are used for alopecia areata, but their long-term use for androgenic alopecia is uncertain.

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