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GlossaryQuiescence

state of cellular dormancy without active division

Quiescence refers to a state of inactivity or dormancy in cells, where they are not actively dividing but are still metabolically active. In the context of hair biology, hair follicle stem cells can enter a quiescent state, pausing their growth and division until they receive signals to re-enter the active phase of the hair growth cycle. This process is crucial for maintaining the long-term health and regenerative capacity of hair follicles.

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research Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors

66 citations, December 2013 in “Nature Cell Biology”

Inactive hair follicle stem cells help prevent skin cancer.

research The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse

2 citations, May 2022 in “Stem cell research & therapy”

Disrupted stem cell signals in hairpoor mice cause hair loss.

A Desmosomal Cadherin Controls Multipotent Hair Follicle Stem Cell Quiescence and Orchestrates Regeneration Through Adhesion Signaling

research A Desmosomal Cadherin Controls Multipotent Hair Follicle Stem Cell Quiescence and Orchestrates Regeneration Through Adhesion Signaling

1 citations, November 2023 in “iScience”

A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.

research KLF4 Maintains Hair Follicle Stem Cell Quiescence

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

KLF4 is important for keeping hair follicle stem cells inactive.

research The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse

October 2021 in “Research Square (Research Square)”

Hair follicle stem cells in hairpoor mice are disrupted, causing hair loss.

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community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 198 upvotes 2 days ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.