A Desmosomal Cadherin Controls Multipotent Hair Follicle Stem Cell Quiescence and Orchestrates Regeneration Through Adhesion Signaling

    November 2023 in “ iScience ”
    William V.J. Hariton, Katja Schulze, Siavash Rahimi … Eliane J. Müller
    Studysummary In this study, researchers found that disrupting desmoglein 3 signaling in a mouse model of pemphigus vulgaris activates normally quiescent hair follicle stem cells, compromising their multipotency but prompting a regenerative response that restores stem cell function and structures.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on doi.org →
    Discuss this study in the Community →

    Research cited in this study 17

    1. Plasticity of Epithelial Cells During Skin Wound Healing Cold Spring Harbor Perspectives in Biology · 2022
    2. Wound-Induced Hair Neogenesis: A Novel Paradigm for Studying Regeneration and Aging Frontiers in Cell and Developmental Biology · 2020
    3. Stem Cell Dynamics, Migration, and Plasticity During Wound Healing Nature Cell Biology · 2018
    4. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    5. Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development Molecular Biology of the Cell · 2018
    6. Modulating the Stem Cell Niche for Tissue Regeneration Nature Biotechnology · 2014
    7. Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin Cold Spring Harbor Perspectives in Medicine · 2014
    8. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    9. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    10. The Stem Cell Niche in Regenerative Medicine Cell stem cell · 2012
    11. Alopecia as a Rare but Distinct Manifestation of Pemphigus Vulgaris Journal of the European Academy of Dermatology and Venereology · 2011
    12. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    13. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    14. Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America · 2005
    15. Expression of Involucrin in Normal, Hyperproliferative, and Neoplastic Mouse Keratinocytes Experimental Dermatology · 2000
    16. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000
    17. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999

    Related research 1

    1. Temporal-Spatial Activation of Wnt-Signaling Within Type 1 and Type 2 Immunity During Wound Healing Journal of Investigative Dermatology · 2019