A Desmosomal Cadherin Controls Multipotent Hair Follicle Stem Cell Quiescence and Orchestrates Regeneration Through Adhesion Signaling

November 2023 in “ iScience ”

William V.J. Hariton, Katja Schulze, Siavash Rahimi, Taravat Shojaeian, Laurence Feldmeyer, Roman Schwob, A. Overmiller, Beyza S. Sayar, Luca Borradori, Mỹ G. Mahoney, Arnaud Galichet, Eliane J. Müller

desmosomal cadherin desmoglein 3 hair follicle stem cell HFSC quiescence regeneration adhesion signaling EGFR activation Wnt modulation Hedgehog signaling HFSC activation multipotency Dsg3 epidermal growth factor receptor Wnt Hedgehog

TLDR A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.

This study investigates the role of desmosomal cadherin, specifically desmoglein (Dsg) 3, in maintaining hair follicle stem cell (HFSC) quiescence and orchestrating regeneration through adhesion signaling using various mouse models. The findings reveal that Dsg3 is crucial for HFSC quiescence and regeneration, involving significant signaling events such as EGFR activation, Wnt modulation, and Hedgehog signaling repression. Disruption of Dsg3 leads to HFSC activation and a regenerative response, highlighting Dsg3's role in preserving HFSC multipotency and providing insights into potential therapeutic targets for hair loss and related conditions.

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