Modulating the Stem Cell Niche for Tissue Regeneration

    August 2014 in “ Nature Biotechnology ”
    Steven Lane, David A. Williams, Fiona M. Watt
    Studysummary This review discusses manipulating the stem cell niche as a strategy in regenerative medicine to repair damaged tissues, highlighting the potential benefits and challenges but reporting no new results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 13

    1. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    2. Small Molecules and Small Molecule Drugs in Regenerative Medicine Drug Discovery Today · 2013
    3. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    4. Potassium Channel Openers Increase Aortic Elastic Fiber Formation and Reverse the Genetically Determined Elastin Deficit in the Brown Norway Rat Hypertension · 2013
    5. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    6. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    7. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    8. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    9. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    10. Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1 Development · 2010
    11. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    12. Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion Current opinion in cell biology · 2008
    13. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007