Potassium Channel Openers Increase Aortic Elastic Fiber Formation and Reverse the Genetically Determined Elastin Deficit in the Brown Norway Rat

    August 2013 in “ Hypertension ”
    Séverin Slove, Morgane Lannoy, Jacques Behmoaras … Marie‐Paule Jacob
    Studysummary The authors concluded that diazoxide reduces undesirable side effects compared to minoxidil while increasing elastic fiber content and decreasing cell number in the aorta, suggesting potential suitability for treating vascular conditions with low arterial elastin and hypertension.
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    Research cited in this study 7

    1. Potassium Channel Therapeutics at the Bedside Journal of Molecular and Cellular Cardiology · 2005
    2. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    3. Effect of Minoxidil on Rabbit Lens Epithelial Cell Behavior In Vitro and In Situ Graefes Archive for Clinical and Experimental Ophthalmology · 2001
    4. Inhibitory Effects of bFGF, VEGF, and Minoxidil on Collagen Synthesis by Cultured Hair Dermal Papilla Cells Archives of Dermatological Research · 1996
    5. Stimulation of Elastin Expression by Minoxidil in Chick Skin Fibroblasts Archives of Dermatological Research · 1995
    6. Minoxidil Stimulates Elastin Expression in Aortic Smooth Muscle Cells Archives of Biochemistry and Biophysics · 1994
    7. The Use of Minoxidil in the Treatment of Severe Essential Hypertension: A Report on 100 Patients Clinical Science · 1976

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    3. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992