Pre-Clinical Cell-Based Therapy for Limbal Stem Cell Deficiency

    August 2015 in “ Journal of functional biomaterials ”
    Amer Sehic, Øygunn Aass Utheim, Kristoffer Ommundsen, Tor Paaske Utheim
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    TLDR Cell-based therapies show promise for treating Limbal Stem Cell Deficiency but need more research.
    The document reviewed various pre-clinical studies on cell-based therapies for treating Limbal Stem Cell Deficiency (LSCD), highlighting the potential of different stem cell sources such as epidermal stem cells, hair follicle-derived stem cells, and bone marrow-derived mesenchymal stem cells. These studies, conducted on animal models, showed promising results in corneal reconstruction with varying degrees of success and minimal complications. The review emphasized the need for further research to identify the most effective cell types and methods for LSCD treatment, as well as the importance of standardized parameters in experiments to improve corneal regenerative medicine.
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