Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1

The study concluded that activating Notch signaling in the adult epidermis led to the accumulation of T cells and neural crest derivatives in the dermis through the upregulation of jagged 1. This process resulted in epidermal thickening, blistering, and hair clumping, with T cell infiltration being responsible for the hair clumping. The findings highlighted the role of Notch signaling in skin inflammation, immune cell recruitment, and the behavior of neural crest-derived cells, providing insights into the molecular mechanisms of skin homeostasis and potential therapeutic targets for skin-related conditions.