Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1

November 2010 in “ Development ”

Carrie A. Ambler, Fiona M. Watt

Notch signaling T cells neural crest derivatives jagged 1 epidermal thickening blistering hair clumping skin inflammation immune cell recruitment skin homeostasis

Studysummary In this study, epidermal Notch activation increased jagged 1 expression, leading to skin changes like thickening and blistering, with these effects inhibited when jagged 1 was absent. Our plain-language summary of this paper — not a Tressless recommendation.

The study concluded that activating Notch signaling in the adult epidermis led to the accumulation of T cells and neural crest derivatives in the dermis through the upregulation of jagged 1. This process resulted in epidermal thickening, blistering, and hair clumping, with T cell infiltration being responsible for the hair clumping. The findings highlighted the role of Notch signaling in skin inflammation, immune cell recruitment, and the behavior of neural crest-derived cells, providing insights into the molecular mechanisms of skin homeostasis and potential therapeutic targets for skin-related conditions.

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