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Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1

research Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1

34 citations , November 2010 in “Development”

In this study, epidermal Notch activation increased jagged 1 expression, leading to skin changes like thickening and blistering, with these effects inhibited when jagged 1 was absent.

research Jagged-1+ Skin Tregs Modulate the Innate Immune Response to Wound Healing

June 2024 in “Research Square (Research Square)”

This study demonstrated that in mice, the absence of Jagged-1 expression in skin-resident regulatory T cells significantly delays wound healing by reducing the accumulation of neutrophils, highlighting the role of Jagged-1 in coordinating immune cell recruitment during injury.

Notch1 Signaling Regulates Wound Healing by Changing the Characteristics of Epidermal Stem Cells

research Notch1 Signaling Regulates Wound Healing via Changing the Characteristics of Epidermal Stem Cells

6 citations , January 2016 in “Journal of Stem Cell Research & Therapy”

This study found that suppressing Jagged1 in epidermal stem cells disrupted Notch signaling and resulted in poor-quality wound healing, suggesting a potential therapeutic target for improving wound repair.

Regulatory T Cells Influence Hair Follicle Cycle and Stem Cell Activation

research Keep your hair on

1 citations , June 2017 in “Nature Reviews Immunology”

Immune cells called Treg cells are essential for hair growth and regeneration.

research Exploring the role of two polypeptide nanofiber gels derived from RADA16-I self-assembly in accelerating burn wound healing

July 2025 in “Scientific Reports”

In this study, peptide nanofiber gels RG and RJ significantly accelerated the healing of deep second-degree burn wounds in vivo, with greater wound closure rates and enhanced tissue regeneration compared to controls, attributed to increased angiogenesis and reduced systemic inflammation.

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community HairLoss after 1 year of inactivity.

4 upvotes 3 years ago

A 17-year-old experiencing early hair loss is advised to improve diet and lose weight gradually, as rapid weight loss and poor diet may contribute to hair loss. Minoxidil is not an option due to tachycardia, and finasteride is not recommended before age 18; alternatives like magnesium oil and dermarolling are suggested.

community I thought I would make a quick public service announcement about haircuts for hairstylists and us

in Update 17 upvotes 7 months ago

Avoid layering thin or thinning hair, as it can make hair appear thinner and uneven. Proper framing and minimal layering can help maintain a fuller look, especially when using treatments like Minoxidil and Finasteride.

community 20yo, dutasteride and minoxidil aren’t working

in Finasteride/Dutasteride 117 upvotes 2 years ago

A 20-year-old reports worsening hair loss despite using dutasteride and minoxidil, and considers a hair transplant. Users suggest continuing treatments, trying microneedling, ketoconazole shampoo, switching to finasteride, or adding tretinoin.

community How come some guys are half bald yet their hair is so healthy?

in Finasteride/Dutasteride 62 upvotes 1 year ago

A 22-year-old male experiencing diffuse thinning and frizzy hair has been using finasteride for nine months and is seeking advice on improving hair quality. Suggestions include using conditioners, biotin, rosemary oil, and addressing scalp conditions like seborrheic dermatitis or psoriasis, while finasteride may help reverse miniaturization and improve hair health.

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learn Epidermal Growth Factor

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