Resident Stem Cells in Skin

January 2013 in “ Elsevier eBooks ”

Radovan Borojević

epidermal stem cells hair follicles interfollicular epidermis sebaceous glands mesenchymal cells dermal components melanocytes dermal papilla cells cell therapies bioengineered skin surrogates skin regeneration skin repair stem cells skin cells

TLDR Skin stem cells can help improve skin repair and regeneration.

The document discussed the hierarchical organization and precise location of stem cell populations in the skin, which is composed of the epidermis and dermis. Epidermal stem cells, located in the upper part of hair follicles, generate interfollicular epidermis, hair, and sebaceous glands, while mesenchymal cells associated with blood vessels in the dermis are the primary source of dermal components. Additionally, exogenous skin cells like melanocytes and dermal papilla cells have their own stem cells. The study highlighted the potential of cell therapies and bioengineered skin surrogates to improve skin regeneration, offering promising solutions for rapid and efficient skin repair.

View this study on sciencedirect.com →

Discuss this study in the Community →

Cited in this study

9 / 9 results

research GMP-Compliant Culture of Human Hair Follicle Cells for Encapsulation and Transplantation

10 citations , January 2012 in “Cell Transplantation”

Researchers successfully grew human hair follicle cells that could potentially lead to new hair loss treatments.

research De Novo Formation and Ultra-Structural Characterization of a Fiber-Producing Human Hair Follicle Equivalent In Vitro

44 citations , March 2011 in “Journal of biotechnology”

Scientists recreated human hair follicles in the lab that can grow hair.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells

63 citations , September 2009 in “Regenerative Medicine”

Scientists found a way to grow human hair cells in a lab that can create new hair when transplanted.

research Microencapsulated Human Hair Dermal Papilla Cells: A Substitute for Dermal Papilla?

25 citations , April 2008 in “Archives of Dermatological Research”

Encapsulated human hair cells can substitute for natural hair cells to grow hair.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

291 citations , October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations , September 2005 in “PLoS biology”

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

2 / 2 results

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae

66 citations , August 2001 in “Experimental Dermatology”

Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.