Molecular Basis of Hair Follicle Donor Dominance in Androgenetic Alopecia and Sexual Dimorphism of the Skin

    April 2017 in “ Journal of Investigative Dermatology ”
    Y. Doucet, Hasan E. Abaci, Colin A.B. Jahoda, J. C. Chen, Angela M. Christiano
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    TLDR Hair loss patterns differ between males and females due to 5 master regulators and JAK-STAT signaling affects hair growth.
    The study aimed to understand the differences in hair loss patterns between males and females and the susceptibility to androgens in certain regions of the scalp. The researchers identified 5 master regulators that mediate molecular differences in skin scalp samples by gender. The study found that some of the top 10 genes differentially expressed in sex-segregated cohorts are associated with mesenchymal components differentiation, suggesting inherent differences in the skin. The authors also found that JAK-STAT signaling promotes hair growth and that inhibiting this pathway can rapidly initiate anagen.
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      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 8 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 9 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community What 3 months without fin& min does😔

      in Progress Pictures  261 upvotes 8 months ago
      Stopping minoxidil and finasteride for three months caused significant hair loss. The user resumed treatment with 2.5mg oral minoxidil and 0.6mg finasteride and plans to update on progress in three months.

      community Why do we get bald from evolutionary perspective

      in Chat  213 upvotes 4 weeks ago
      Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 11 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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