Molecular Basis of Hair Follicle Donor Dominance in Androgenetic Alopecia and Sexual Dimorphism of the Skin

April 2017 in “ Journal of Investigative Dermatology ”

Y. Doucet, Hasan E. Abaci, Colin A.B. Jahoda, J. C. Chen, Angela M. Christiano

androgenetic alopecia androgens JAK-STAT signaling anagen mesenchymal components male pattern baldness female pattern baldness JAK inhibitors

TLDR Hair loss patterns differ between males and females due to 5 master regulators and JAK-STAT signaling affects hair growth.

The study aimed to understand the differences in hair loss patterns between males and females and the susceptibility to androgens in certain regions of the scalp. The researchers identified 5 master regulators that mediate molecular differences in skin scalp samples by gender. The study found that some of the top 10 genes differentially expressed in sex-segregated cohorts are associated with mesenchymal components differentiation, suggesting inherent differences in the skin. The authors also found that JAK-STAT signaling promotes hair growth and that inhibiting this pathway can rapidly initiate anagen.

View this study on jidonline.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community What else is good. Besides the big 3.

in Chat 34 upvotes 2 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community What 3 months without fin& min does😔

in Progress Pictures 261 upvotes 1 month ago

Stopping minoxidil and finasteride for three months caused significant hair loss. The user resumed treatment with 2.5mg oral minoxidil and 0.6mg finasteride and plans to update on progress in three months.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 2020 Hair and Scalp Treatments: A Clinical Guide (in Depth 350 Page Guide)

in Treatment 64 upvotes 4 years ago

Treatments for hair loss, including topical immunotherapy, regenerative treatments, laser and light-based therapies, oral supplements, intralesional steroids, and new drugs like finasteride and minoxidil.

community I’ve been on dutesteride and oral minoxidil for two years now and I’ve only lost ground…

in Treatment 42 upvotes 10 months ago

A user on dutasteride and oral minoxidil for two years reports worsening hair loss and is seeking advice. Suggestions include consulting a professional for underlying causes, acknowledging that treatments don't work for everyone, and considering dosage adjustments or additional treatments.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 2 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

Related Research

14 / 14 results

research Androgenetic Alopecia: Clinical Treatment

2 citations, September 2019 in “Springer eBooks”

research Androgenetic Alopecia and Its Remedies: A Review

August 2014 in “Journal of drug discovery and therapeutics”

Topical minoxidil and oral finasteride can help regrow hair in androgenetic alopecia.

research Cell Biology and Disease of Hair Follicle: Pathomechanism and Treatment of Androgenetic Alopecia

January 2013 in “The Nishinihon Jourrnal of Dermatology”

research Epigenetic Modifications May Explain the Relative Protection of Occipital Hair Follicles from Androgenetic Alopecia in Men

1 citations, July 2011 in “Hair transplant forum international”

research Male Androgenetic Alopecia Is Due to Hair Follicle Stem Cell Inactivation

3 citations, April 2011 in “Expert Review of Dermatology”

Male hair loss is caused by inactive hair follicle stem cells.

research Molecular Basis of Androgenetic Alopecia

11 citations, January 2010 in “Springer eBooks”

research Male Pattern Baldness: An Update

January 2009 in “Revista de Ciências Médicas”

Male pattern baldness is a genetic condition causing hair loss, with limited but improving treatment options.

research Male Androgenetic Alopecia

17 citations, December 2004 in “The Journal of Men's Health & Gender”

Male pattern baldness involves hormone-related hair thinning, shorter hair, and inflammation.

research Hair Loss Unrelated to Androgenetic Alopecia

2 citations, March 2004

research Histological Findings in Androgenetic Alopecia

January 1996 in “Springer eBooks”

Balding doesn't reduce the number of hair follicles, it just makes them smaller.

research Androgenetic Alopecia: Some Thoughts and Views About Its Topical Treatment

January 1989 in “Springer eBooks”