TLDR Hair loss patterns differ between males and females due to 5 master regulators and JAK-STAT signaling affects hair growth.
The study aimed to understand the differences in hair loss patterns between males and females and the susceptibility to androgens in certain regions of the scalp. The researchers identified 5 master regulators that mediate molecular differences in skin scalp samples by gender. The study found that some of the top 10 genes differentially expressed in sex-segregated cohorts are associated with mesenchymal components differentiation, suggesting inherent differences in the skin. The authors also found that JAK-STAT signaling promotes hair growth and that inhibiting this pathway can rapidly initiate anagen.
October 2021 in “QJM: An International Journal of Medicine”
October 2021 in “QJM: An International Journal of Medicine”
February 2021 Caffeine can potentially treat common hair loss by counteracting hair follicle shrinkage caused by hormones.
2 citations
,
January 2020 in “Springer eBooks”
August 2014 in “Journal of drug discovery and therapeutics”
January 2013 in “The Nishinihon Jourrnal of Dermatology” 1 citations
,
July 2011 in “Hair transplant forum international”
3 citations
,
April 2011 in “Expert Review of Dermatology” Male hair loss is caused by inactive hair follicle stem cells.
11 citations
,
January 2010 in “Springer eBooks”
January 2009 in “Revista de Ciências Médicas” Male pattern baldness is a genetic condition causing hair loss, with limited but improving treatment options.
17 citations
,
December 2004 in “The Journal of Men's Health & Gender” Male pattern baldness involves hormone-related hair thinning, shorter hair, and inflammation.
January 1996 in “Springer eBooks” Balding doesn't reduce the number of hair follicles, it just makes them smaller.
January 1989 in “Springer eBooks”