Male Pattern Baldness: An Update

The document from 2009 discusses androgenetic alopecia, commonly known as male pattern baldness, which is characterized by symmetrical hair loss in the frontal hairline and scalp vertex. The condition, which affects up to 50% of white males by the age of 50, is genetically determined and linked to the androgen receptor. Although it does not pose serious health risks, it can impact quality of life. Recent advances have improved the understanding of hair growth cycles and the pathogenesis of androgenetic alopecia, revealing that it involves the shortening of growth cycles and thinning of the scalp follicles, a process known as miniaturization. While many genes may contribute to the condition, only the androgen receptor gene has been definitively implicated. The article also summarizes various treatment options for male androgenetic alopecia, including minoxidil, but notes that few treatments have been effectively proven.