Impairment of Autophagy May Be Associated with Follicular Miniaturization in Androgenetic Alopecia by Inducing Premature Catagen

December 2020 in “ Journal of Dermatology ”

Wei-Wen Liu, Kaitao Li, Gaofeng Wang, Lunan Yang, Qian Qu, Zhiqi Hu, Yang-Kook Sun, Junfei Huang, Yong Miao

autophagy androgenetic alopecia catagen hair follicles terminal hairs vellus hairs autophagy-related proteins hair loss balding scalp

TLDR Impaired autophagy may cause hair loss by triggering early catagen.

Impaired autophagy may be associated with hair loss in androgenetic alopecia by causing premature catagen, leading to the degradation of hair follicles and the transformation of terminal hairs into vellus. The study proposes targeting autophagy as a potential treatment for this condition. Autophagy-related proteins were found to be reduced in balding scalp, and inhibiting autophagy led to reduced hair growth. However, more research is needed to fully comprehend this link and develop effective treatments.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy

research Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy

20 citations, June 2019 in “Experimental Dermatology”

The research suggests that autophagy-related genes might play a role in causing alopecia areata.

research Stimulation of Hair Growth by Small Molecules That Activate Autophagy

88 citations, June 2019 in “Cell reports”

Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.

research Androgenetic Alopecia: Causes, Treatments, and Genetic Factors

1 citations, July 2018 in “Elsevier eBooks”

Heredity and hormones cause common hair loss, and topical minoxidil is the first recommended treatment.

research Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture

42 citations, March 2018 in “PLOS Biology”

Autophagy is important for human hair growth and health.

research Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq

8 citations, December 2017 in “Skin appendage disorders”

WNT7A gene expression is higher in early stages of androgenetic alopecia, showing the role of WNT pathway, apoptosis, and inflammation in the disorder.

research A Guide to Studying Human Hair Follicle Cycling In Vivo

212 citations, September 2015 in “Journal of Investigative Dermatology”

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

research Androgenetic Alopecia: An Evidence-Based Treatment Update

151 citations, May 2014 in “American Journal of Clinical Dermatology”

Effective treatments for male pattern baldness include oral finasteride and topical minoxidil, while topical minoxidil is best for female pattern baldness.

research An Overview of Alopecias

53 citations, March 2014 in “Cold Spring Harbor Perspectives in Medicine”

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

research Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture

132 citations, September 2009 in “Experimental Dermatology”

A reliable system was developed to distinguish hair growth stages, aiding in identifying hair growth promoters or inhibitors.

research Proliferation, DNA Repair, and Apoptosis in Androgenetic Alopecia

19 citations, January 2009 in “Journal of The European Academy of Dermatology and Venereology”

Bald areas have lower cell growth, more DNA damage, and increased cell death.

research Changes in Different Melanocyte Populations During Hair Follicle Involution (Catagen)

40 citations, November 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different melanocyte types in hair follicles either survive or die during the catagen phase.

research Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss

116 citations, September 2001 in “Journal of The American Academy of Dermatology”

Hair loss occurs due to fewer papillary cells, smaller follicles, and shorter growth phases.

Similar Research

5 / 724 results

Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

research Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

15 citations, May 2020 in “BMC complementary medicine and therapies”

Polygonum multiflorum extract helps hair grow longer and fights the effects of hormones that cause hair loss.

research Triton Modified Polyethyleneimine Conjugates Assembled With Growth Arrest-Specific Protein 6 for Androgenetic Alopecia Transdermal Gene Therapy

February 2023 in “Materials today bio”

The treatment effectively promotes hair regrowth in androgenetic alopecia without causing skin irritation.

research Bioactive Compound-Loaded Nanocarriers for Hair Growth Promotion: Current Status and Future Perspectives

October 2023 in “Plants”

Nanocarriers with plant extracts show promise for safe and effective hair growth treatment.

research Aging and Anti-Aging in Hair and Hair Loss

1 citations, September 2013 in “Elsevier eBooks”

Hair ages and thins due to factors like inflammation and stress, and treatments like antioxidants and hormones might improve hair health.

research Re-Densification Effect of Pressure-Injected Peptide-Hyaluronic Acid Combination on Male Androgenic Alopecia

January 2024 in “Journal of Cosmetics, Dermatological Sciences and Applications”

Injecting a peptide-hyaluronic acid mix improved hair growth in men with hair loss and was safe.