Advancements in Bioactive Compounds and Therapeutic Agents for Alopecia: Trends and Future Perspectives

December 2025 in “ Cosmetics ”

Eunmiri Roh

alopecia areata androgenetic alopecia baricitinib ritlecitinib dihydrotestosterone follicular miniaturization minoxidil platelet-rich plasma intracellular signaling pathways stem cell organoids exosome-based therapeutics microbial homeostasis mitochondrial homeostasis AA AGA DHT Rogaine PRP

TLDR New treatments for alopecia show promise in restoring hair growth by targeting immune and hormonal factors.

The review highlights recent advancements in treating alopecia, focusing on alopecia areata (AA) and androgenetic alopecia (AGA). It emphasizes the role of immune, endocrine, metabolic, and microbial systems, with pathways like JAK/STAT and Wnt/BMP being crucial. JAK inhibitors such as baricitinib and ritlecitinib have shown promise in large studies, like BRAVE-AA1/AA2 with 1,200 participants, for AA. For AGA, combination therapies like low-dose oral minoxidil and platelet-rich plasma are promising. Innovative approaches, including stem cell organoids and exosome-based therapeutics, aim to reconstruct hair follicles. The review underscores the importance of microbial homeostasis and redox stability for long-term hair regeneration, suggesting a multimodal approach integrating various mechanisms for improved hair growth and resilience.

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