Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq
December 2017
in “
Skin appendage disorders
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TLDR WNT7A gene expression is higher in early stages of androgenetic alopecia, showing the role of WNT pathway, apoptosis, and inflammation in the disorder.
This study used targeted RNA-Seq to evaluate the expression of genes associated with inflammation and apoptosis in androgenetic alopecia (AGA). The study found that the WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. CASP7 and TNF genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder. The study included 10 patients with AGA and 2 control subjects. The study suggests that targeted RNA-Seq is a useful technique for the evaluation of gene expression in AGA samples.
