Mechanism of Apoptotic Regulation of Follicular Regression
June 2001
in “
American Journal of Pathology
”
hair follicle cyclic regression regeneration follicular bulge stem cells pathological hair loss p53 apoptosis catagen phase gene alterations organogenesis tissue remodeling hair follicle hair cycle hair growth stem cells hair loss p53 cell death catagen phase gene changes organ development tissue repair
TLDR The document concludes that understanding how hair follicles naturally die and regenerate is important for insights into organ development and could impact health and disease treatment.
The document from June 1, 2001, emphasizes the complexity of the hair follicle and its significance in cyclic regression and regeneration, a process vital for survival as it prevents continuous hair growth. It notes that the follicular bulge contains stem cells essential for hair regeneration and that damage to different parts of the follicle can lead to pathological hair loss. The document references a study by Botchkarev et al., which found that the transcription factor p53 plays a role in the apoptosis-driven regression of hair follicles, with p53 knockout mice exhibiting a delayed catagen phase and gene alterations related to this phase. The findings underscore the importance of understanding the molecular mechanisms behind follicular regression and renewal for broader insights into organogenesis and tissue remodeling, with potential implications for human health and disease.
