This letter contains an apology from the author to Dr. Malkinson for remarks that were unintentionally offensive, acknowledging Dr. Malkinson's superior understanding of the discussed problem.
33 citations
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September 1961 in “Archives of Dermatology”
This letter clarifies that colchicine induces anagen hairloss, as shown in animal studies, and corrects a misquotation by Kligman, who suggested it caused telogen effluvium.
1 citations
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May 2003 in “Archives of Pathology & Laboratory Medicine”
This report discusses a case of pediatric trichotillomania, detailing its clinical presentation and distinguishing histopathological characteristics, ultimately diagnosing the condition in a 7-year-old boy with nonscarring alopecia.
4 citations
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January 2017 in “JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH”
In this study, alopecia areata was identified as the most common cause of hairloss in children, with histopathological findings similar to those in adults.
Hairloss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hairloss persisting due to high testosterone and GPR133's role.
Bryan Johnson's new hairloss product, which includes peptides, is viewed skeptically by many, with concerns it may be a money grab rather than an effective treatment. Most users prefer proven treatments like finasteride and minoxidil, which are cheaper and have established results.
Microneedling can aid hair regrowth but poses risks like permanent hairloss if not done properly. Combining it with minoxidil, finasteride, and tretinoin, while ensuring proper sterilization and technique, is crucial for safety and effectiveness.
Hair cloning is seen as a distant and potentially less relevant solution for hairloss due to its high cost, invasiveness, and the advancement of other treatments like Minoxidil and finasteride. Many believe that by the time hair cloning becomes viable, other less invasive and more effective treatments will be available.
Hairloss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.
Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.
Can a zinc deficiency directly cause hair thinning or increased shedding?Studies link low serum zinc to diffuse shedding and alopecia areata, and severe deficiency states cause hair loss that reverses when zinc is replaced. The evidence is mostly observational, the one supplementation study was small and uncontrolled, and zinc is not a treatment for pattern hair loss.
Got small bald patches they say are from stress? PP405 sprays could help bring them back to life.PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.