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    Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

    May 2020 in “ BMC complementary medicine and therapies ”
    Jae Young Shin, Yun Ho Choi, Jaeyoon Kim … Sang Hwa Lee
    Studysummary This study found that Polygonum multiflorum extract may promote hair growth by increasing anagen duration and activating dermal papilla cells in human hair follicles, as observed in cultured cell models.
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    Research cited in this study 37

    1. Prevention of Lipid Loss from Hair by Surface and Internal Modification Scientific reports · 2019
    2. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    3. Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis-Induced Hair Loss BioMed Research International · 2018
    4. Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal npj Regenerative Medicine · 2017
    5. Androgenetic Alopecia: A Review Endocrine · 2017
    6. The Role of the VEGF, KGF, EGF, and TGF-β1 Growth Factors in the Pathogenesis of Telogen Effluvium in Women Biomedical and Pharmacology Journal · 2017
    7. Hair Growth Promoting Effects of Emodin in Telogenic C57BL/6 Mice Korean journal of veterinary research · 2016
    8. Epidermal Growth Factor Promotes Proliferation of Dermal Papilla Cells via Notch Signaling Pathway Biochimie · 2016
    9. Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments Oxidative medicine and cellular longevity · 2016
    10. Enhancement of Human Hair Growth Using Ecklonia Cava Polyphenols Annals of Dermatology · 2016
    11. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    12. Hair Growth Promotion Activity and Its Mechanism of Polygonum Multiflorum Evidence-based Complementary and Alternative Medicine · 2015
    13. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013
    14. Promotion Effect of Constituents from the Root of Polygonum Multiflorum on Hair Growth Bioorganic & Medicinal Chemistry Letters · 2013
    15. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    16. Androgenetic Alopecia: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    17. VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK Experimental Cell Research · 2012
    18. Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice Journal of Ethnopharmacology · 2011
    19. 5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine Journal of acupuncture and meridian studies · 2010
    20. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    21. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    22. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    23. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006
    24. The Hair Cycle Journal of Cell Science · 2006
    25. Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression Journal of Investigative Dermatology · 2005
    26. Pathogenesis of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2004
    27. Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle Experimental Dermatology · 2003
    28. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    29. An Investigation of Apoptosis in Androgenetic Alopecia PubMed · 2003
    30. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    31. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    32. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    33. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    34. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    35. The Hair Follicle: A Paradoxical Androgen Target Organ Hormone Research in Paediatrics · 2000
    36. Hair Follicle Apoptosis And Bcl-2 Journal of Investigative Dermatology Symposium Proceedings · 1999
    37. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998

    Related research 4

    1. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    2. Relation Between Dermal Papilla Cells and Androgenetic Alopecia International Journal of Dermatology and Venereology · 2010
    3. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    4. Hormonal Interaction And Hair Growth PubMed · 2002