Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

    January 2016 in “ Oxidative medicine and cellular longevity ”
    Shuang Ling, Jin‐Wen Xu
    TLDR THSG from a Chinese plant helps with aging and related diseases.
    The document reviewed the biological activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside (THSG) in antiaging and related disease treatments. THSG exhibited significant antioxidant, anti-inflammatory, and neuroprotective properties, showing promise in treating cardiovascular diseases, improving cognitive function, and managing metabolic disorders. It demonstrated neuroprotective effects in Alzheimer's and Parkinson's disease models, reduced oxidative stress, and inhibited apoptosis in neuronal cells. THSG also promoted hair growth in mice, protected bone density, and improved diabetic complications. Despite its potential, the regulatory mechanisms and functional targets of THSG remained unclear, and high concentrations might have toxicological effects. Most studies used animal models with dosages ranging from 20 to 150 mg/kg.
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