Topical Administration of 15-Deoxy-Δ12,14-Prostaglandin J2 Using a Nonionic Cream: Effect on UVB-Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice

    January 2021 in “ Mediators of Inflammation ”
    Clovis M. Kumagai, Renata M. Martínez, Bárbara B. Colombo, Priscila Saito, Ingrid C. Pinto, Camilla C. A. Rodrigues, David L. Vale, Ricardo Luís Nascimento de Matos, Ana Paula Frederico Rodrigues Loureiro Bracarense, Marcela M. Baracat, Sandra R. Georgetti, Juliana Trindade Clemente‐Napimoga, Marcelo Henrique Napimoga, Victor Fattori, Waldiceu A. Verri, Rúbia Casagrande
    Studysummary In this study, 15d-PGJ2 administered in a topical cream inhibited oxidative and inflammatory skin changes caused by UVB radiation in hairless mice, suggesting it as a promising treatment approach.
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    The study investigated the effects of a topical formulation containing 15-deoxy-Δ12,14-prostaglandin J2 (TFcPGJ2) on UVB-induced skin damage in 168 hairless mice. The results showed that TFcPGJ2 significantly reduced inflammation markers such as skin edema, myeloperoxidase activity, and metalloproteinase-9 activity, and improved antioxidant markers, indicating a protective effect against oxidative stress. The treatment also reduced sunburn cell formation, mast cell recruitment, collagen fiber degradation, and epidermal thickening. These findings suggested that TFcPGJ2 could potentially serve as a therapeutic agent to prevent UVB-induced skin damage.
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