Topical Administration of 15-Deoxy-Δ12,14-Prostaglandin J2 Using a Nonionic Cream: Effect on UVB-Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice

January 2021 in “ Mediators of Inflammation ”

Clovis M. Kumagai, Renata M. Martínez, Bárbara B. Colombo, Priscila Saito, Ingrid C. Pinto, Camilla C. A. Rodrigues, David L. Vale, Ricardo Luís Nascimento de Matos, Ana Paula Frederico Rodrigues Loureiro Bracarense, Marcela M. Baracat, Sandra R. Georgetti, Juliana Trindade Clemente‐Napimoga, Marcelo Henrique Napimoga, Victor Fattori, Waldiceu A. Verri, Rúbia Casagrande

15-Deoxy-Δ12,14-prostaglandin J2 UVB-induced skin damage oxidative stress inflammation antioxidant capabilities nonionic cream

TLDR 15d‐PGJ2 cream protects against UVB-induced skin damage in mice.

The study investigated the effects of a topical formulation containing 15-deoxy-Δ12,14-prostaglandin J2 (TFcPGJ2) on UVB-induced skin damage in 168 hairless mice. The results showed that TFcPGJ2 significantly reduced inflammation markers such as skin edema, myeloperoxidase activity, and metalloproteinase-9 activity, and improved antioxidant markers, indicating a protective effect against oxidative stress. The treatment also reduced sunburn cell formation, mast cell recruitment, collagen fiber degradation, and epidermal thickening. These findings suggested that TFcPGJ2 could potentially serve as a therapeutic agent to prevent UVB-induced skin damage.

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research Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species

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Topical Administration of 15-Deoxy-Δ12,14-Prostaglandin J2 Using a Nonionic Cream: Effect on UVB-Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice

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