Promotion Effect of Constituents from the Root of Polygonum Multiflorum on Hair Growth

July 2013 in “ Bioorganic & Medicinal Chemistry Letters ”

Ya Nan Sun, Long Cui, Wei Li, Xi Tao Yan, Seo Young Yang, Jung Il Kang, Hee Kyoung Kang, Young Ho Kim

Polygonum multiflorum compound 2 minoxidil dermal papilla cells torachrysone stilbenes anthraquinone derivatives alopecia Rogaine

Studysummary This study found that compound 2 from Polygonum multiflorum significantly increased dermal papilla cell proliferation and hair-fiber length, suggesting potential as a therapeutic agent for alopecia. Our plain-language summary of this paper — not a Tressless recommendation.

In a 2013 study, researchers found that certain compounds extracted from the root of Polygonum multiflorum, particularly a new compound labeled as compound 2, had a significant effect on promoting hair growth. This compound was more effective than minoxidil, a common hair growth treatment, in increasing the proliferation of dermal papilla cells at concentrations of 10 and 20 µM. Additionally, compound 2 at 1 µM increased hair-fiber length in rat vibrissa follicle cultures by 135.5 ± 15.5% over 21 days. The study suggests that compound 2, along with other identified compounds such as torachrysone, stilbenes, and anthraquinone derivatives, could be potential treatments for alopecia. The number of subjects used in the study was not specified.

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