In Vivo Hair Growth-Promoting Efficacies of Herbal Extracts and Their Cubosomal Suspensions

    January 2013 in “ Journal of Industrial and Engineering Chemistry ”
    Seung Ree Seo, Gu Hyun Kang, Jeong Wook Ha, Jin‐Chul Kim
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    TLDR Some herbal extracts, especially when used in cubosomal suspensions, were as effective as Minoxidil in promoting hair growth.
    The study from 2013 examined the effects of six herbal extracts and their cubosomal suspensions on promoting hair growth in C57BL/6 male mice. The extracts tested were from Poria cocos, Thuja orientalis, Espinosilla, Lycium chinense Mill, Coix lacryma-jobi, and Polygonum multiflorum Thunberg. These were applied daily for 20 days, and their efficacy was compared to a 2.4% Minoxidil solution. The results showed that the extracts from Thuja orientalis, Polygonum multiflorum Thunberg, and Espinosilla were effective in promoting hair growth. The use of cubosomes, which are known to enhance skin permeation, significantly increased the efficacy of the herbal extracts. The cubosomal suspensions containing the herbal extracts were found to be as effective as the Minoxidil solution, as evidenced by the measurement of hair regrowth areas and histological observations of hair follicles.
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