Epidermal Growth Factor Promotes Proliferation of Dermal Papilla Cells via Notch Signaling Pathway

    April 2016 in “ Biochimie ”
    Haihua Zhang, Weixiao Nan, Shiyong Wang, Tietao Zhang, Huazhe Si, Datao Wang, Fenghuan Yang, Guangyu Li
    TLDR A substance called epidermal growth factor helps increase the growth of important hair follicle cells by activating a specific cell communication route.
    The study demonstrated that epidermal growth factor (EGF) had a dual effect on mink hair follicles and dermal papilla (DP) cells in vitro, depending on its concentration. Low doses of EGF (2-20 ng/ml) promoted hair follicle growth and DP cell proliferation, while a high dose (200 ng/ml) inhibited follicle growth. EGF facilitated the G1/S cell cycle transition and upregulated mesenchymal markers and follicle-regulatory genes via the Notch signaling pathway. Inhibition of the Notch pathway reduced both basal and EGF-enhanced DP cell proliferation, highlighting the pathway's critical role in mediating EGF's effects on hair growth.
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