Epidermal Growth Factor Promotes Proliferation of Dermal Papilla Cells via Notch Signaling Pathway

August 2016 in “ Biochimie ”

Haihua Zhang, Weixiao Nan, Shiyong Wang, Tietao Zhang, Huazhe Si, Datao Wang, Fenghuan Yang, Guangyu Li

epidermal growth factor dermal papilla cells Notch signaling pathway hair follicles G1/S cell cycle transition mesenchymal markers follicle-regulatory genes EGF DP cells

TLDR A substance called epidermal growth factor helps increase the growth of important hair follicle cells by activating a specific cell communication route.

The study demonstrated that epidermal growth factor (EGF) had a dual effect on mink hair follicles and dermal papilla (DP) cells in vitro, depending on its concentration. Low doses of EGF (2-20 ng/ml) promoted hair follicle growth and DP cell proliferation, while a high dose (200 ng/ml) inhibited follicle growth. EGF facilitated the G1/S cell cycle transition and upregulated mesenchymal markers and follicle-regulatory genes via the Notch signaling pathway. Inhibition of the Notch pathway reduced both basal and EGF-enhanced DP cell proliferation, highlighting the pathway's critical role in mediating EGF's effects on hair growth.

View this study on sciencedirect.com →

Discuss this study in the Community →

Cited in this study

12 / 12 results

research Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline

211 citations , April 2013 in “Development”

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.

research The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization

131 citations , February 2010 in “Experimental Dermatology”

The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

330 citations , December 2009 in “Cell stem cell”

SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

research Survivin in the Human Hair Follicle

28 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Survivin protein is crucial for hair growth and preventing cell death in hair follicles.

research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway

113 citations , October 2005 in “Journal of Investigative Dermatology”

Applying a special compound can promote hair growth without harmful side effects.

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle

94 citations , July 2003 in “Journal of biological chemistry/The Journal of biological chemistry”

EGF controls hair growth by regulating hair follicles' growth phases.

research Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations

54 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Disruptions in hair follicle fibroblast dynamics can cause hair growth problems.

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

research Effects of EGF on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations , February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.

research Mouse notch: expression in hair follicles correlates with cell fate determination.

150 citations , May 1993 in “The journal of cell biology/The Journal of cell biology”

Mouse Notch is important for determining cell roles in hair follicles.

research Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro

58 citations , January 1987 in “Archives of Dermatological Research”

EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.

4 / 4 results

research Reorganization of Hair Follicles in Human Skin Organ Culture Induced by Cultured Human Follicle-Derived Cells

56 citations , July 2005 in “Experimental Dermatology”

Injected human hair follicle cells can create new, small hair follicles in skin cultures.

research Study on Hair Follicle Formation Induced by Dermal Papilla Cells

January 2003 in “Chinese Journal of Reparative and Reconstructive Surgery”

Dermal papilla cells can help form hair follicles and produce hair.

research Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells

61 citations , October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

research Effects of EGF on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations , February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.