Epidermal Growth Factor Promotes Proliferation of Dermal Papilla Cells via Notch Signaling Pathway

April 2016 in “ Biochimie ”

Haihua Zhang, Weixiao Nan, Shiyong Wang, Tietao Zhang, Huazhe Si, Datao Wang, Fenghuan Yang, Guangyu Li

epidermal growth factor dermal papilla cells Notch signaling pathway hair follicles G1/S cell cycle transition mesenchymal markers follicle-regulatory genes EGF DP cells

Studysummary This study shows that the concentration of epidermal growth factor (EGF) is crucial for determining whether mink hair follicles are promoted or inhibited in vitro, with involvement of the Notch signaling pathway in DP cell proliferation.

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research Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle

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research Mouse Notch: Expression in Hair Follicles Correlates with Cell Fate Determination

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