Epidermal Growth Factor Promotes Proliferation of Dermal Papilla Cells via Notch Signaling Pathway

    April 2016 in “ Biochimie ”
    Haihua Zhang, Weixiao Nan, Shiyong Wang, Tietao Zhang, Huazhe Si, Datao Wang, Fenghuan Yang, Guangyu Li
    TLDR A substance called epidermal growth factor helps increase the growth of important hair follicle cells by activating a specific cell communication route.
    The study demonstrated that epidermal growth factor (EGF) had a dual effect on mink hair follicles and dermal papilla (DP) cells in vitro, depending on its concentration. Low doses of EGF (2-20 ng/ml) promoted hair follicle growth and DP cell proliferation, while a high dose (200 ng/ml) inhibited follicle growth. EGF facilitated the G1/S cell cycle transition and upregulated mesenchymal markers and follicle-regulatory genes via the Notch signaling pathway. Inhibition of the Notch pathway reduced both basal and EGF-enhanced DP cell proliferation, highlighting the pathway's critical role in mediating EGF's effects on hair growth.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 55 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Vitamin C and hair growth PH levels

      in Product  31 upvotes 2 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

    Related Research

    4 / 4 results