Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis-Induced Hair Loss

The study from 2018 examined the effects of Tetrahydroxystilbene Glucoside (TSG) on hair loss and found that TSG significantly promoted hair regrowth in depilated C57BL/6J mice, with a hair-covered skin ratio of 91% ± 5.3% and hair length of 1.40 ± 0.6 mm after 2 weeks of treatment. This result was more favorable than those observed in the vehicle and Minoxidil groups. The research also demonstrated that TSG treatment decreased the expression of apoptosis-related proteins such as p53, Bax, Active Caspase-3, and Procaspase-9, while increasing the Bcl-2/Bax ratio. This suggests that TSG can regulate the Bax-mediated intrinsic apoptotic pathway. Furthermore, TSG significantly suppressed the Fas gene, which may indicate that inhibition of the Fas-mediated apoptotic pathway also contributes to hair regrowth. The study suggests TSG as a potential alternative treatment for hair loss conditions like alopecia and telogen effluvium, although the number of mice used in the study was not mentioned.