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GlossaryTumor Suppressor Gene (TSG)

regulates cell growth by preventing uncontrolled cell division

A tumor suppressor gene is a type of gene that helps regulate cell growth by preventing cells from dividing too quickly or in an uncontrolled way. When these genes are mutated or inactivated, it can lead to the development of cancer because the normal checks on cell division are lost. Examples include the TP53 gene, which produces a protein that can trigger cell death if DNA damage is detected, thereby preventing the propagation of potentially cancerous cells.

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research The Effects of Finasteride on the Expression of Dazl, Tsga10, Sycp3, Prm2 Genes During Spermatogenesis in Testes of NMRI Mice

August 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Finasteride, at doses of 5mg or higher, may negatively affect male fertility by reducing the expression of certain genes involved in sperm production.

research Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis-Induced Hair Loss

9 citations, January 2018 in “BioMed Research International”

Tetrahydroxystilbene Glucoside may help prevent hair loss by blocking certain pathways that lead to cell death.

research Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Regeneration After Facial Nerve Injury

6 citations, February 2022 in “The journal of neuroscience/The Journal of neuroscience”

Deleting the PTEN gene in mice causes nerve cells to grow larger and heal better after injury, but may cause overgrowth and hair loss in older mice.

research Exploring the Role of UC-MSC-Derived Exosomes in Boosting HHDPCs Proliferation for Hair Growth via AKT Activation

January 2024

UC-MSC-derived exosomes may help treat hair loss by promoting hair cell growth through AKT activation.

research BRCA2 in Abscission: Role in Cytokinesis and Recruitment of Abscission Regulators

August 2012 in “Nature Cell Biology”

The tumor suppressor BRCA2 helps in cell division by bringing key proteins to the area where cells split.

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community Surprisingly thorough study on He-Shou-Wu/Fo Ti

in Research/Science 14 upvotes 1 year ago

He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.