2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside (TSG) from Polygonum Multiflorum Thunb.: A Systematic Review on Anti-Aging

    April 2025 in “ International Journal of Molecular Sciences ”
    Zhu Can, Jinhong Li, Wenchao Tang, Yaofeng Li, Chang Lin, Deliang Peng, Changfu Yang
    TLDR TSG from Polygonum multiflorum may help with anti-aging by protecting the brain, heart, bones, and hair.
    The systematic review examines the anti-aging properties of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb., highlighting its potential in extending lifespan and combating age-related diseases such as Alzheimer's, Parkinson's, cardiovascular issues, osteoporosis, and promoting hair regrowth. TSG functions by reducing oxidative stress, inflammation, and apoptosis, while enhancing mitochondrial function and telomerase activity. Despite promising preclinical results, the translation into clinical applications is limited by a lack of robust clinical evidence and research biases. Future studies should focus on large-scale clinical trials to establish TSG's efficacy and safety for global clinical use.
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