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    Glossary Mitophagy

    Mitophagy is a selective form of autophagy that specifically targets damaged or dysfunctional mitochondria for degradation. This process is crucial for maintaining cellular health, as it helps prevent the accumulation of defective mitochondria that can contribute to oxidative stress and cellular aging, both of which are relevant to hair loss. In the context of hair biology, impaired mitophagy may lead to reduced energy production and increased cellular stress in hair follicles, potentially exacerbating conditions like androgenetic alopecia. Key distinguishing characteristics of mitophagy include its reliance on specific receptors that recognize damaged mitochondria and the involvement of autophagosomes in the degradation process.

    Research 10 of 204

    1. The crosstalk between PTEN ‐induced kinase 1‐mediated mitophagy and the inflammasome in the pathogenesis of alopecia areata Experimental Dermatology · 2023 · 6 citations
    2. The regulatory mechanisms of mitophagy and oxidative stress in androgenetic alopecia Cellular Signalling · 2025
    3. Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis Theranostics · 2024
    4. 1330 The possible role of PTEN-induced kinase 1-mediated mitophagy by regulating inflammasome activation in the pathogenesis of alopecia areata 2023
    5. Protective mitophagy in human hypoxic cardiomyocytes: mechanistic insights into SGLT2 inhibitor Dapagliflozin cardioprotection in ischemic injury Research Square · 2026
    6. The walking dead: sequential nuclear and organelle destruction during hair development British Journal of Dermatology · 2017 · 16 citations
    7. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging International Journal of Molecular Sciences · 2025 · 3 citations
    8. A NIR-responsive PDA@RES core-shell nanoplatform accelerates chronic wound healing by remodeling mitochondrial homeostasis and reversing cellular senescence Nano Research · 2026
    9. Remolding Microenvironmental Homeostasis for Enhancing Regenerative Hypertrophic Scar Treatment Based on Functionalized Microneedles Interdisciplinary materials · 2025
    10. Autophagy Dysfunction: The Kernel of Hair Loss? Clinical Cosmetic and Investigational Dermatology · 2024
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