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    Glossary Mitophagy

    Mitophagy is a selective form of autophagy that specifically targets damaged or dysfunctional mitochondria for degradation. This process is crucial for maintaining cellular health, as it helps prevent the accumulation of defective mitochondria that can contribute to oxidative stress and cellular aging, both of which are relevant to hair loss. In the context of hair biology, impaired mitophagy may lead to reduced energy production and increased cellular stress in hair follicles, potentially exacerbating conditions like androgenetic alopecia. Key distinguishing characteristics of mitophagy include its reliance on specific receptors that recognize damaged mitochondria and the involvement of autophagosomes in the degradation process.

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    Research 30 of 187

    1. The crosstalk between PTEN ‐induced kinase 1‐mediated mitophagy and the inflammasome in the pathogenesis of alopecia areata Experimental Dermatology · 2023 · 6 citations
    2. The regulatory mechanisms of mitophagy and oxidative stress in androgenetic alopecia Cellular Signalling · 2025
    3. Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis Theranostics · 2024
    4. 1330 The possible role of PTEN-induced kinase 1-mediated mitophagy by regulating inflammasome activation in the pathogenesis of alopecia areata 2023
    5. Protective mitophagy in human hypoxic cardiomyocytes: mechanistic insights into SGLT2 inhibitor Dapagliflozin cardioprotection in ischemic injury Research Square · 2026
    6. The walking dead: sequential nuclear and organelle destruction during hair development British Journal of Dermatology · 2017 · 16 citations
    7. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging International Journal of Molecular Sciences · 2025 · 3 citations
    8. A NIR-responsive PDA@RES core-shell nanoplatform accelerates chronic wound healing by remodeling mitochondrial homeostasis and reversing cellular senescence Nano Research · 2026
    9. Remolding Microenvironmental Homeostasis for Enhancing Regenerative Hypertrophic Scar Treatment Based on Functionalized Microneedles Interdisciplinary materials · 2025
    10. Autophagy Dysfunction: The Kernel of Hair Loss? Clinical Cosmetic and Investigational Dermatology · 2024
    11. Advances in mitochondria-centered mechanism behind the roles of androgens and androgen receptor in the regulation of glucose and lipid metabolism Frontiers in endocrinology · 2023
    12. Mechanisms of autophagy and their implications in dermatological disorders Frontiers in Immunology · 2024 · 6 citations
    13. A guide to studying human dermal adipocytes in situ Experimental Dermatology · 2018 · 21 citations
    14. Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update Mechanisms of Ageing and Development · 2018 · 19 citations
    15. From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet? Molecular and Cellular Endocrinology · 2017 · 17 citations
    16. Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice Biomedicine & Pharmacotherapy · 2020 · 9 citations
    17. Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing Frontiers in Immunology · 2024 · 7 citations
    18. The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels ACS Medicinal Chemistry Letters · 2024 · 6 citations
    19. The Charnoly body as a universal biomarker of cell injury Biomarkers and Genomic Medicine · 2014 · 6 citations
    20. LncRNA-miRNA-mRNA regulatory networks in skin aging and therapeutic potentials Frontiers in physiology · 2023 · 3 citations
    21. H2AK119ub dynamics control hair follicle stem cell quiescence Nature Communications · 2025 · 2 citations
    22. Progeroide Syndrome Die Dermatologie · 2023 · 2 citations
    23. Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats Scientific Reports · 2025 · 1 citations
    24. Causality of Aging Hallmarks Aging and Disease · 2025 · 1 citations
    25. Montagna Symposium 2017—Precision Dermatology: Next Generation Prevention, Diagnosis, and Treatment 2018 · 1 citations
    26. The role of protein lactylation in skin diseases: from molecular mechanisms to potential therapeutics Frontiers in Immunology · 2026
    27. Homeodynamic Rejuvenation: an adaptive framework for resetting skin aging Frontiers in Aging · 2026
    28. Skin aging: mechanisms, evaluation, and rejuvenation The EMBO Journal · 2026
    29. Nanotechnological reprogramming of the pathological skin microenvironment in scar formation and atopic dermatitis Journal of Pharmaceutical Investigation · 2026
    30. The orchestrated network of skin photoaging: From intercellular crosstalk to molecular signaling BioScience Trends · 2026