Recombinant Human TSG-6 Ameliorates Delayed Wound Healing in Mice with Diet-Induced Diabetes

This study investigates the effects of recombinant human Tumor Necrosis Factor Stimulated Gene 6 (rhTSG6) on wound healing in a diabetic mouse model. Mice were divided into four groups, and rhTSG6 was administered to assess its impact on wound closure. The results showed that rhTSG6 significantly accelerated wound healing in diabetic mice, with a notable improvement by day 7 compared to diabetic mice receiving a vehicle treatment (p=0.0004). The treatment also reduced pro-inflammatory markers such as IL-6, VEGF, and TNF-α in diabetic mice. These findings suggest that rhTSG6 has potential as a therapeutic agent for diabetic chronic wounds, although further research is needed to optimize its use and understand its mechanisms.