Helminth TGF-β Mimic, TGM, Increases Leukocyte Migration and Activation While Also Enhancing Cutaneous Wound Healing and Tissue Regeneration

The study conducted by researchers from Rutgers University New Jersey Medical School and University of Glasgow, United Kingdom, found that TGF-β mimic (TGM), a molecule secreted by the intestinal parasite Heligmosomoides polygyrus, can enhance wound healing. In an in vivo wound biopsy model, TGM was topically administered and resulted in greater restoration of normal tissue structure, accelerated re-epithelialization, and hair follicle regeneration without increased scarring. The study also observed enhanced early accumulation and persistence of migratory Ly6C+ macrophages in TGM-treated wounds during the early inflammatory phase, and increased CD301b+ myeloid populations at mid-stage wound healing. These findings suggest that TGM could be a potential novel therapeutic option for enhanced wound healing.