TLDR Helminth protein helps wounds heal better by reducing scarring and promoting tissue growth.
The study demonstrates that a helminth-derived TGF-β mimic (TGM) significantly enhances wound healing by inhibiting fibrosis and promoting tissue regeneration. In murine models, TGM-treated wounds showed improved closure rates, increased hair follicle and sebaceous gland development, and more favorable collagen orientation, resembling normal skin. TGM reprograms macrophages to favor regenerative healing over fibrotic scarring, with reduced aSMA expression indicating lower myofibroblast activation. The study involved 5 mice per treatment group and highlights TGM's potential as a novel, bioactive, and stable therapeutic agent for wound care, offering advantages over current treatments.
66 citations,
May 2021 in “Science Advances” Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.
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