TLDR Treg cells help repair and regenerate tissues by interacting with local cells.
The review "Treg–tissue cell interactions in repair and regeneration" examines the role of regulatory T (Treg) cells in tissue repair and regeneration, highlighting their interactions with various tissue cells such as epithelial, mesenchymal, and endothelial cells. Treg cells produce mediators like amphiregulin (Areg) and cytokines (e.g., IL-10, TGF-β) that aid in processes like wound healing, hair follicle regeneration, and recovery from lung, muscle, and brain injuries. The review underscores Treg cells' dual role in immunosuppression and direct tissue repair, suggesting potential therapeutic applications for enhancing tissue repair in clinical settings. Further research is needed to understand Treg cells' functions in chronic diseases and cancer.
188 citations,
March 2018 in “Frontiers in Immunology” Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.
1 citations,
December 2022 in “Frontiers in Immunology” Tissue environment greatly affects the unique epigenetic makeup of regulatory T cells, which could impact autoimmune disease treatment.
3 citations,
October 2023 in “Military Medical Research/Military medical research” Regulatory T cells help heal skin and grow hair, and their absence can lead to healing issues and hair loss.
9 citations,
March 2022 in “Frontiers in Immunology” Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.
40 citations,
March 2019 in “Nature Communications” CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.
