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GlossaryRegulatory T Cells (Treg cells)

specialized immune cells that prevent autoimmune responses

Regulatory T Cells, often abbreviated as Tregs, are a specialized subset of T cells in the immune system that help maintain immune tolerance and prevent autoimmune diseases. They function by suppressing the activity of other immune cells, thereby preventing excessive or misdirected immune responses that could damage the body's own tissues.

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research Stepwise Acquisition of Unique Epigenetic Signatures During Differentiation of Tissue Treg Cells

1 citations, December 2022 in “Frontiers in Immunology”

Tissue environment greatly affects the unique epigenetic makeup of regulatory T cells, which could impact autoimmune disease treatment.

Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

research Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

30 citations, July 2019 in “PloS one”

Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.

research Tissue Resident and Follicular Treg Cell Differentiation Is Regulated by CRAC Channels

40 citations, March 2019 in “Nature Communications”

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

research Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

31 citations, February 2014 in “Inflammation Research”

Lower CD200R1 on certain immune cells is linked to more severe rheumatoid arthritis and immune imbalance.

research Regulating Hair Follicle Stem Cells

14 citations, June 2017 in “Immunity”

Special immune cells called Treg cells are important for maintaining and regenerating hair by activating a specific growth signal in hair stem cells.

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