Regulatory T Cells in Skin Regeneration and Wound Healing

    Samuel Knoedler, Leonard Knoedler, Martin Kauke-Navarro … Adriana C. Panayi
    Studysummary This review explores the crucial role of regulatory T cells in skin wound healing, emphasizing their involvement in balancing immune responses and promoting regeneration. It also discusses Tregs' operations in fibrosis, keloidosis, and scarring, suggesting a potential avenue for novel treatments.
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    Research cited in this study 25

    1. Cellular Activation Pathways and Interaction Networks in Vascularized Composite Allotransplantation Frontiers in Immunology · 2023
    2. The Expanding Impact of T-Regulatory Cells in Skin Health Frontiers in Immunology · 2022
    3. Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice Frontiers in immunology · 2022
    4. Alopecia Areata: Current Understanding and Management Journal der Deutschen Dermatologischen Gesellschaft · 2022
    5. Skin Stem Cells Orchestrate De Novo Generation of Extrathymic Regulatory T Cells to Establish a Temporary Protective Niche During Wound Healing bioRxiv (Cold Spring Harbor Laboratory) · 2021
    6. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    7. Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation Frontiers in Cell and Developmental Biology · 2020
    8. Epidermal Stem Cells in Wound Healing and Regeneration Stem Cells International · 2020
    9. Frontiers in Alopecia Areata Pathobiology Research ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2019
    10. Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease PloS one · 2019
    11. The Dynamics of the Skin’s Immune System International Journal of Molecular Sciences · 2019
    12. Regulatory T Cells in Inflammatory Skin Disease: From Mice to Humans International immunology · 2019
    13. Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals Molecular Biology and Evolution · 2018
    14. Regulatory T Cells in Autoimmune Skin Diseases Experimental Dermatology · 2018
    15. Regulatory T Cells Are Required for Normal and Activin-Promoted Wound Repair in Mice European Journal of Immunology · 2018
    16. Regulatory T Cells in Skin: Role of Foxp3+ CD4+ Tregs in Skin Homeostasis and Immune Tolerance Immunology · 2017
    17. Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin Cell host & microbe · 2017
    18. Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions Advances in wound care · 2016
    19. Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing British Journal of Dermatology · 2015
    20. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    21. Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues ˜The œjournal of immunology/˜The œJournal of immunology · 2013
    22. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    23. Scratching the Surface of Skin Development Nature · 2007
    24. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    25. Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata Journal of Investigative Dermatology · 2002